Human Leukocyte Transcriptional Response to SARS-CoV-2 Infection
Clinics; 75 (), 2020
Results: 12
Overexpression of bHLH domain of HIF-1 failed to inhibit the HIF-1 transcriptional activity in hypoxia
Biol. Res; 53 (), 2020
BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is considered as the most activated transcriptional factor in response to low oxygen level or hypoxia. HIF-1 binds the hypoxia response element (HRE) sequence in the promoter of different genes, mainly through the bHLH domain and activates the transcription ...
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo, Hipoxia/metabolismo, Factor 1 Inducible por Hipoxia/metabolismo, Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética, Western Blotting, Expresión Génica, Células HEK293, Hipoxia/genética, Factor 1 Inducible por Hipoxia/genética, Reacción en Cadena en Tiempo Real de la Polimerasa, Activación Transcripcional/genética
Notoginsenoside R1 upregulates miR-221-3p expression to alleviate ox-LDL-induced apoptosis, inflammation, and oxidative stress by inhibiting the TLR4/NF-κB pathway in HUVECs
Braz. j. med. biol. res; 53 (6), 2020
Atherosclerosis (AS) is a common vascular disease, which can cause apoptosis of vascular endothelial cells. Notoginsenoside R1 (NGR1) is considered an anti-AS drug. MicroRNAs (miRNAs) are believed to play a vital role in cell apoptosis and angiogenesis. This study aimed to explore the mechanism of NGR1 f...
Apoptosis/efectos de los fármacos, Western Blotting, Ensayo de Inmunoadsorción Enzimática, Ginsenósidos/farmacología, Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos, Células Endoteliales de la Vena Umbilical Humana/metabolismo, Inmunoprecipitación, Inflamación/metabolismo, Lipoproteínas LDL/metabolismo, MicroARNs/efectos adversos, MicroARNs/metabolismo, FN-kappa B/antagonistas & inhibidores, Estrés Oxidativo/efectos de los fármacos, Especies Reactivas de Oxígeno, Reacción en Cadena en Tiempo Real de la Polimerasa, Transducción de Señal, Receptor Toll-Like 4/antagonistas & inhibidores, Activación Transcripcional, Regulación hacia Arriba
FSH receptor binding inhibitor up-regulates ARID1A and PTEN genes associated with ovarian cancers in mice
Braz. j. med. biol. res; 52 (7), 2019
Experiments were conducted to determine if the follicle-stimulating hormone (FSH) receptor binding inhibitor (FRBI) impacts the expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) in ovaries and blood, as well as expressions of follicle...
Western Blotting, Proteínas de Unión al ADN/sangre, Proteínas de Unión al ADN/metabolismo, Hormona Folículo Estimulante/metabolismo, Proteínas Nucleares/sangre, Proteínas Nucleares/metabolismo, Neoplasias Ováricas/metabolismo, Fosfohidrolasa PTEN/sangre, Fosfohidrolasa PTEN/metabolismo, Fosforilación, Reacción en Cadena en Tiempo Real de la Polimerasa, Receptores de HFE/antagonistas & inhibidores, Factores de Transcripción, Activación Transcripcional/genética, Regulación hacia Arriba
lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11
Braz. j. med. biol. res; 52 (10), 2019
The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3), a tumor suppressor, is critical for the carcinogenesis and progression of different cancers, including hepatocellular carcinoma (HCC). To date, the roles of lncRNA MEG3 in HCC are not well illustrated. Therefore, this study used western...
Apoptosis/genética, Carcinoma Hepatocelular/genética, Carcinoma Hepatocelular/metabolismo, Carcinoma Hepatocelular/patología, Línea Celular Tumoral, Proliferación Celular/genética, Regulación Neoplásica de la Expresión Génica, Neoplasias Hepáticas/genética, Neoplasias Hepáticas/metabolismo, Neoplasias Hepáticas/patología, MicroARNs/genética, MicroARNs/metabolismo, Estadificación de Neoplasias, ARN Largo no Codificante/genética, ARN Largo no Codificante/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa, Factores de Transcripción SOXC/genética, Factores de Transcripción SOXC/metabolismo, Activación Transcripcional, Transfección, Regulación hacia Arriba
Molecular cloning and subcellular localization of six HDACs and their roles in response to salt and drought stress in kenaf (Hibiscus cannabinus L)
Biol. Res; 52 (), 2019
BACKGROUND: Histone acetylation is an important epigenetic modification that regulates gene activity in response to stress. Histone acetylation levels are reversibly regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). The imperative roles of HDACs in gene transcription, trans...
Hibiscus/enzimología, Histona Acetiltransferasas/fisiología, Histona Desacetilasas/fisiología, Estrés Fisiológico/fisiología, Sequías, Hibiscus/crecimiento & desarrollo, Hibiscus/fisiología, Activación Transcripcional/fisiología, Reacción en Cadena en Tiempo Real de la Polimerasa, Clonación Molecular
PDK2 promotes chondrogenic differentiation of mesenchymal stem cells by upregulation of Sox6 and activation of JNK/MAPK/ERK pathway
Braz. j. med. biol. res; 50 (2), 2017
This study was undertaken to clarify the role and mechanism of pyruvate dehydrogenase kinase isoform 2 (PDK2) in chondrogenic differentiation of mesenchymal stem cells (MSCs). MSCs were isolated from femurs and tibias of Sprague-Dawley rats, weighing 300-400 g (5 females and 5 males). Overexpression and ...
Diferenciación Celular, Condrogénesis/fisiología, Proteínas Quinasas JNK Activadas por Mitógenos/fisiología, Sistema de Señalización de MAP Quinasas/fisiología, Células Madre Mesenquimatosas/fisiología, Proteínas Serina-Treonina Quinasas/fisiología, Ratas Sprague-Dawley, Factores de Transcripción SOXE/fisiología, Activación Transcripcional, Regulación hacia Arriba
20 years of RET/PTC in thyroid cancer: clinico-pathological correlations
Arq. bras. endocrinol. metab; 51 (5), 2007
The RET/PTC oncogene has been isolated almost twenty years ago. During these years, the research has given a final answer to several questions. In fact, it has been demonstrated that: a) RET/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the pa...
Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer
Arq. bras. endocrinol. metab; 51 (5), 2007
Apoptosis is an essential physiological process of elimination of destined cells during the development and differentiation or after damage from external stresses such as ionizing radiation or chemotherapeutic agents. Disruption of apoptosis is proved to cause various diseases including cancer. Among num...
Potencial oncogênico de variantes naturais de papilomavírus humano
O principal fator etiológico da neoplasia do colo do útero é a infecção por HPVs (papilomavírus humano) de alto risco oncogênico, principalmente HPVs 16 e 18. a variabilidade intra-típica de ambos tipos virais tem sido extensivamente estudada. A análise da diversidade genética de isolados oriun...