LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294

Samer, Sadia; Arif, Muhammad Shoaib; Giron, Leila Bertoni; Zukurov, Jean Paulo Lopes; Hunter, James; Santillo, Bruna Teresa; Namiyama, Gislene; Galinskas, Juliana; Komninakis, Shirley Vasconcelos; Oshiro, Telma Miyuki; Sucupira, Maria Cecilia; Janini, Luiz Mario; Diaz, Ricardo Sobhie.

Braz. j. infect. dis; 24 (2), 2020

ABSTRACT Background: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n = 17) for the first time in comparison to a combination of methyltransferase inhibitors (MTIs; Chaetocin and BI...

Azepinas/farmacología, Infecciones por VIH/virología, VIH-1/efectos de los fármacos, Metiltransferasas/antagonistas & inhibidores, Niacinamida/farmacología, Quinazolinas/farmacología, Activación Viral/efectos de los fármacos, Linfocitos T CD4-Positivos, Regulación Viral de la Expresión Génica, Leucocitos Mononucleares/virología, Piperazinas/farmacología, Carga Viral/efectos de los fármacos, Tropismo Viral/efectos de los fármacos, Latencia del Virus

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Challenging management of hepatitis B infection in ankylosing spondylitis patients in an endemic area during immunosuppressive therapy

Nunes, Gabriel Pacífico Seabra; Cunha, Patrícia da Silva; Bosco, Daniele Patrícia Dal; Ribeiro, Sandra Lúcia Euzébio.

Rev. Soc. Bras. Med. Trop; 52 (), 2019

Abstract Hepatitis B infection is a global health issue. When considering patients with rheumatic diseases, this is no different. By using immunosuppressant drugs, such as DMARDs and biologics, viral reactivation is possible, leading to serious consequences on the patient. We report 3 cases of associatio...

Antirreumáticos/efectos adversos, Antirreumáticos/uso terapéutico, Enfermedades Endémicas, Hepatitis B/inmunología, Inmunosupresores/efectos adversos, Inmunosupresores, Espondilitis Anquilosante, Activación Viral/efectos de los fármacos

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Alemtuzumab as graft-versus-host disease (GVHD) prophylaxis strategy in a developing country: lower rate of acute GVHD, increased risk of cytomegalovirus reactivation

Resende, CB; Rezende, BM; Bernardes, PTT; Teixeira, GM; Teixeira, MM; Pinho, V; Bittencourt, H.

Braz. j. med. biol. res; 50 (2), 2017

Acute graft-versus-host disease (aGVHD) and cytomegalovirus reactivation are important complications after allogeneic stem cell transplantation (alloHSCT). Here, we evaluated the impact of treatment with alemtuzumab on the occurrence of aGVHD, cytomegalovirus reactivation and survival after alloHSCT. Thi...

Alemtuzumab, Anticuerpos Monoclonales Humanizados/uso terapéutico, Citomegalovirus/fisiología, Infecciones por Citomegalovirus/prevención & control, Supervivencia sin Enfermedad, Enfermedad Injerto contra Huésped/prevención & control, Enfermedad Injerto contra Huésped/virología, Trasplante de Células Madre Hematopoyéticas/efectos adversos, Trasplante de Células Madre Hematopoyéticas/métodos, Estudios Prospectivos, Factores de Riesgo, Trasplante Homólogo, Activación Viral/efectos de los fármacos

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Genotoxicity of plant extracts

Vargas, Vera M. F; Guidobono, Régis R; Henriques, João A. P.

Mem. Inst. Oswaldo Cruz; 86 (supl.2), 1991

Aqueous extracts of seven species used in Brazilian popular medicine (Achyrocline satureoides, Iodina rhombifolia, Desmodium incanum, Baccharis anomala, Tibouchina asperior, Luehea divaricata, Maytenus ilicifolia) were screened to the presence of mutagenic activity in the Ames test (Salmonella/microsome)...

Brasil, Microsomas Hepáticos/metabolismo, Pruebas de Mutagenicidad, Mutágenos/toxicidad, Extractos Vegetales/toxicidad, Plantas Medicinales, Ratas Sprague-Dawley, Respuesta SOS en Genética/efectos de los fármacos, Salmonella typhimurium/efectos de los fármacos, Activación Viral/efectos de los fármacos, Agua

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