Impact of sodium butyrate and mild hypothermia on metabolic and physiological behaviour of CHO TF 70R cells
Electron. j. biotechnol; 27 (), 2017
Background: To reduce costs associated with productivity of recombinant proteins in the biopharmaceutical industry, research has been focused on regulatory principals of growth and survival during the production phases of the cell culture. The main strategies involve the regulation of cell proliferation ...
Células CHO/metabolismo, Células CHO/fisiología, Proteínas Recombinantes/metabolismo, Hipotermia, Ácido Butírico/metabolismo, Proliferación Celular, Activador de Tejido Plasminógeno/metabolismo, Activador de Tejido Plasminógeno/biosíntesis, Supervivencia Celular, Ciclo Celular, Potencial de la Membrana Mitocondrial