Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
Mem. Inst. Oswaldo Cruz; 114 (), 2019
BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of ...
Antimonio/farmacología, Acuagliceroporinas/metabolismo, Resistencia a Medicamentos/efectos de los fármacos, Resistencia a Medicamentos/genética, Leishmania braziliensis/efectos de los fármacos, Leishmania braziliensis/genética, Leishmaniasis Cutánea/parasitología, Reacción en Cadena en Tiempo Real de la Polimerasa