LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model

Li, Rong; He, Miaoqing; Wu, Bing; Zhang, Peng; Zhang, Qinbin; Chen, Yangmei.

Braz. j. med. biol. res; 53 (4), 2020

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as ...

Medicamentos Herbarios Chinos/uso terapéutico, Epilepsia del Lóbulo Temporal/inducido químicamente, Epilepsia del Lóbulo Temporal/tratamiento farmacológico, Agonistas de Aminoácidos Excitadores/metabolismo, Pentilenotetrazol, Proteínas Serina-Treonina Quinasas/metabolismo, Ratas Sprague-Dawley, Receptores AMPA/metabolismo

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Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures

L-Glutamate (L-Glu), the major excitatory neurotransmitter in the mammalian Central Nervous System (CNS), is essential to cognitive functions. However, when L-Glu is accumulated in large concentrations at the synaptic cleft, it can induce excitotoxicity that results in secondary damage implicated in many...