Adenosine a1 receptor agonist protects against hippocampal neuronal injury after lithium chloride-pilocarpine-induced epilepsy
Rev. invest. clín; 71 (2), 2019
Abstract Background Adenosine A1 receptor (AA1R) is widely present in the central nervous system, exerting brain protective antiepileptic effects, mainly by binding corresponding G proteins. We evaluated the neuroprotective effects of AA1R on hippocampal neuronal injury after lithium chloride-pilocarpin...
Agonistas del Receptor de Adenosina A1/farmacología, Apoptosis/efectos de los fármacos, Modelos Animales de Enfermedad, Epilepsia/tratamiento farmacológico, Hipocampo/efectos de los fármacos, Hipocampo/patología, Cloruro de Litio/toxicidad, Neuronas/patología, Fármacos Neuroprotectores/farmacología, Pilocarpina/toxicidad, Ratas Sprague-Dawley, Factores de Tiempo