Abstract BACKGROUND: Tacrolimus, for its activity on modulation of collagen production and fibroblast activity, may have a role in the prevention of hypertrophic scars. OBJECTIVES: Evaluate macroscopic, microscopic, metabolic, laboratory effects and side effects of the use of topical tacrolimus ointmen...
SUMMARY: We sought to investigate the potential protective effect of Vitamin E supplementation against hepatocyte ultrastructural alterations induced by high fat diet (HFD) in a rat model of pre-diabetes. Therefore, rats were either fed with HFD (model group) or a standard laboratory chow (control group)...
ABSTRACT PURPOSE : To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS : Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20 mg/kg TPP was injected to intraperitonea...
ABSTRACT PURPOSE: To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS: Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were su...
We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II IV received 250, 500 and 750 mg/kg bodyweight of metha...
Evaluation of the enzymes alanine aminotransferase, aspartate aminotransferase, alkaline phofatase and creatine-phosphate-kinase in dogs subjected to a weekly administration of ivermectin
Estudou-se a influência da administraçäo semanal de ivermectina, em cäes, sobre as enzimas alanina-aminotransferase, aspartato-aminotransferase, fosfatase alcalina e creatinina-fosfoquinase. Utilizaram-se 15 cäes sem raça definida (peso médio de 7kg), distribuídos em três grupos. Foram realizada...
