Abstract Albendazole is an anthelmintic drug commonly used in parenchymal neurocysticercosis and cystic echinococcosis. The aim of this study was to explore whether disparities in the dissolution profiles of albendazole products lead to significant differences in pharmacokinetic parameters. Three generic...
Albendazole and fenbendazole are imidazole derivatives that exhibit broad spectrum activity against parasites, but the low solubility of these drugs considerably reduces their effectiveness. Complexation of albendazole and fenbendazole with cyclodextrins (β-cyclodextrin and hydroxypropyl-β-cyclodextrin...
The aim of this study was to characterize three batches of albendazole by pharmacopeial and complementary analytical techniques in order to establish more detailed specifications for the development of pharmaceutical forms. The ABZ01, ABZ02, and ABZ03 batches had melting points of 208 ºC, 208 ºC, and 2...
Albendazole is a broad-spectrum benzimidazole anthelmintic recently introduced in the pharmaceutical market. A new volumetric dosage method is proposed, in nonaqueous medium with sodium methylate using DMF as eluent, for albendazole analytical determination as raw material and in tablets. The equivalence...
Albendazol - anti-helmintico benzimidazolico de amplo espectro recentemente introduzido ao mercado terapeutico nacional - foi determinado quantitativamente em meio nao-aquoso, com acido perclorico, tanto como materia-prima, quanto na forma de comprimidos. O ponto final e melhor determinado potenciometric...
O albendazol foi analisado por metodos fisicos, fisico-quimicos e quimicos. Comprimidos de duas especialidades contendo albendazol tambem foram analisados por esses metodos. Alem disto a estabilidade termica do farmaco foi observada por diversas tecnicas. Concluiu-se que: 1)O teste de caracterizacao mais...
