Antileishmanial agents: synthesis of allopurinol prodrugs for oral administration
Rev. farm. bioquim. Univ. Säo Paulo; 31 (2), 1995
Synthesis of six prodrugs of allopurinol (4-hydroxypyrazolo-(3,4-d)pyrimidine) is described. These compounds were given orally to male and female BALB/C (sensitive) and C57BL/6 (partially resistant) strains of mice, wich had been previously infected with Leishmania mexicana. The results show that at end ...