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Synthesis and Biological Activity of Trolox Amide Derivatives

Xu, Qian; Zhang, Luyun; Xia, Guangqing; Zhan, Dazhao; Zhu, Junyi; Zang, Hao.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract A series of Trolox amide derivatives were synthesized by modifying the carboxyl groups of Trolox. Thirty target compounds were obtained and characterized through nuclear magnetic resonance and mass spectrometry. Trolox derivatives were employed to explore the potential structure-antioxidant act...
Antioxidantes/análisis, Espectroscopía de Resonancia Magnética/métodos, Espectrometría de Masas/métodos, Amidas/agonistas, Inhibidores de la Colinesterasa/efectos adversos, Productos Biológicos/análisis, Acarbosa/efectos adversos
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Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

Kasabova-Angelova, Alexandra; Kondeva-Burdina, Magdalena; Mitkov, Javor; Georgieva, Maya; Tzankova, Virginia; Zlatkov, Alexander.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neurotoxic ...
Amidas/agonistas, Cafeína/antagonistas & inhibidores, Células/clasificación, Economía, Encéfalo/patología, Fármacos Neuroprotectores/análisis, Glutatión/farmacología, Neuroprotección, Oxidopamina, Supervivencia Celular, Sinaptosomas
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