LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice

Sensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive effect of amifostine and its potential neuroprotective mechanisms on the oxaliplatin-related peripheral sensory neuropathy in mice. Oxaliplatin (1 mg/kg) was injected intra...

Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation

Barbosa, S C M; Pereira, V B M; Wong, D V T; Santana, A P M; Lucetti, L T; Carvalho, L L; Barbosa, C R N; Callado, R B; Silva, C A A; Lopes, C D H; Brito, G A C; Alencar, N M N; Lima-Júnior, R C P.

Braz. j. med. biol. res; 52 (3), 2019

Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti...

Amifostina/uso terapéutico, Cricetinae, Modelos Animales de Enfermedad, Fluorouracilo/efectos adversos, Inflamación/inducido químicamente, Inflamación/patología, Inflamación/prevención & control, Sustancias Protectoras/uso terapéutico, Estomatitis/inducido químicamente, Estomatitis/patología, Estomatitis/prevención & control, Xerostomía/inducido químicamente, Xerostomía/patología, Xerostomía/prevención & control

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