LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Direct spectrofluorimetric methods as alternatives to compendial ones used for the quality control of biopharmaceuticals: development, validation and application

Souza, Thallis Martins; Angelino, Robert da Silva; Ornella, Larissa Manhães; Ribeiro, Eduardo dos Santos; Fernandes, Simone Ferreira Rodrigues.

Braz. J. Pharm. Sci. (Online); 60 (), 2024

Abstract A simple, rapid, precise, accurate and sustainable spectrofluorimetric method (SFM) was developed, validated and applied for the determination of 4-aminobenzoic acid and aromatic amino acids (phenylalanine, tryptophan and tyrosine). These compounds are used in biopharmaceutical formulations and ...

Control de Calidad, Productos Biológicos/clasificación, Ácido 4-Aminobenzoico/agonistas, Aminoácidos Aromáticos/efectos adversos, Espectrometría de Fluorescencia/métodos, d0068630

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A review of experimental models in colorectal carcinogenesis

Colorectal cancer is the leading cause of malignancy of the gastrointestinal tract. A better understanding of the molecular and cellular changes that lead to the disease is necessary to develop early diagnosis and optimal treatment modalities. Rodent models are rapid, reproducible and exhibit an adenoma-...