ABSTRACT Myoblasts fuse into multinucleated muscle fibers to form and promote the growth of skeletal muscle. In order to analyze the role of myostatin (MSTN) in body fat, skeletal muscle cell proliferation and differentiation and energy metabolism, this study will use the antisense RNA technology of gene...
BACKGROUND: Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology and pathogenesis of MS remain unknown. RESULTS: In this study, the integration of t...
Clinically relevant biomarkers are useful to determine cancer patients' prognosis and treatments. To discover new putative biomarkers, we performed in silico analysis of a 325-gene panel previously associated with breast epithelial cell biology and clinical outcomes. Sixteen public datasets of microarray...
Cryptococcal meningitis affects normal hosts and immunocompromised patients exhibiting high mortality rates. The objective of this study was to design two molecular assays, visible microarray platforms and loop-mediated isothermal amplification (LAMP), to identify Cryptococcus spp. and the species neofor...
Background: Gene expression analysis via microarray is widely used in phytobacteria to validate differential gene expression associated with virulence or to compare biological profiles of wild type and mutant strains. Here, we employed DNA microarrays to study the early stages of the infection process (2...
Xanthomonas/genética,
Xanthomonas/patogenicidad,
Análisis de Secuencia por Matrices de Oligonucleótidos,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Expresión Génica,
Genes Bacterianos,
Virulencia,
Citrus sinensis/microbiología,
Xanthomonas/crecimiento & desarrollo,
Transcriptoma,
Sistemas de Secreción Tipo III
Abstract Background Mitochondrial and oxidative stress has been related to obesity and breast cancer being this cancer more frequent and more aggressive in postmenopausal women with obesity. Objective The objective of this study was to investigate whether Mexican-Mestizo postmenopausal women with breas...
Análisis de Secuencia por Matrices de Oligonucleótidos,
Obesidad/epidemiología,
México,
Mastectomía Segmentaria/métodos,
Mastectomía/métodos,
Genoma Mitocondrial,
ADN Mitocondrial/genética,
Neoplasias de la Mama/cirugía,
Neoplasias de la Mama/patología,
Neoplasias de la Mama/genética,
Índice de Masa Corporal,
Polimorfismo Genético,
Posmenopausia
Yu, Cheng Hao;
Zhao, Jin Shuang;
Zhao, Hui;
Peng, Teng;
Shen, Dong Cheng;
Xu, Qiu Xia;
Li, Yao;
Webb, R. Clinton;
Wang, Mong Heng;
Shi, Xing Ming;
Peng, Cheng;
Ding, Wei Jun.
The aim of this study was to elucidate the concise effects of a traditional herb pair, Curcumae rhizoma-Sparganii rhizoma (CRSR), on uterine leiomyoma (UL) by analyzing transcriptional profiling. The UL rat model was made by intramuscular injection of progesterone and gavage administration of diethylstil...
Curcuma/química,
Modelos Animales de Enfermedad,
Regulación Neoplásica de la Expresión Génica/efectos de los fármacos,
Leiomioma/tratamiento farmacológico,
Leiomioma/genética,
Leiomioma/metabolismo,
Análisis de Secuencia por Matrices de Oligonucleótidos,
Extractos Vegetales/farmacología,
Radioinmunoensayo,
Ratas Sprague-Dawley,
Rizoma/química,
Factores de Transcripción,
Neoplasias Uterinas/tratamiento farmacológico,
Neoplasias Uterinas/genética,
Neoplasias Uterinas/metabolismo
Ciertas cepas de Escherichia coli productoras de toxina Shiga (STEC) tienen la capacidad de formar biofilm en alimentos y otras superficies, aumentando su potencial como fuente de contaminación. El gen fimH se ha asociado a la capacidad de formación de biofilm en E.coli. Este estudio observacional desc...
Molck, Miriam Coelho;
Simioni, Milena;
Vieira, Társis Paiva;
Sgardioli, Ilária Cristina;
Monteiro, Fabíola Paoli;
Souza, Josiane;
Fett-Conte, Agnes Cristina;
Félix, Têmis Maria;
Monlléo, Isabella Lopes;
Gil-da-Silva-Lopes, Vera Lúcia.
Abstract Objective: To identify pathogenic genomic imbalances in patients presenting congenital heart disease (CHD) with extra cardiac anomalies and exclusion of 22q11.2 deletion syndrome (22q11.2 DS). Methods: 78 patients negative for the 22q11.2 deletion, previously screened by fluorescence in situ h...
