LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Engeletin protects against cerebral ischemia/reperfusion injury by modulating the VEGF/vasohibin and Ang-1/Tie-2 pathways

Engeletin is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity and suppresses lipid peroxidation. In the present study, we sought to elucidate the mechanistic basis for the neuroprotective and pro-angiogenic activity of engeltin in a human umbilical vein endothelia...

Vascular endothelial growth factor association with angiopoietin 1 promotes improvement in ventricular function after ischemic cardiomyopathy induced in mini pigs

Oliveira, André Lacerda de Abreu; Scheffer, Jussara Peters; Markoski, Melissa; Koche, Andreia; Balbinot, Alexsandra; Antunes, Fernanda; Kalil, Renato.

Acta cir. bras; 33 (4), 2018

Abstract Purpose: To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. Methods: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarct...

Angiopoyetina 1/uso terapéutico, Tratamiento Basado en Trasplante de Células y Tejidos/métodos, Modelos Animales de Enfermedad, Ecocardiografía, Terapia Genética/métodos, Hemodinámica/fisiología, Infarto del Miocardio/patología, Infarto del Miocardio/fisiopatología, Infarto del Miocardio/terapia, Necrosis, Neovascularización Fisiológica, Reproducibilidad de los Resultados, Porcinos, Porcinos Enanos, Resultado del Tratamiento, Factor A de Crecimiento Endotelial Vascular/uso terapéutico, Función Ventricular/fisiología, Cicatrización de Heridas

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