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Evaluation of Telomerase (hTert), Ki67 and p16ink4a expressions in low and high-grade cervical intraepithelial lesions

GOULART, ANA PAULA SZEZEPANIAK; GONÇALVES, MANOEL AFONSO GUIMARÃES; DA-SILVA, VINICIUS DUVAL.
Rev. Col. Bras. Cir; 44 (2), 2017
ABSTRACT Objective : to study the association between the histological grading of cervical intraepithelial neoplasia (CIN I, CIN II and CIN III) and the immunohistochemical expression for p16ink4a, hTert and Ki67, as well as to evaluate the relationship of these markers with the risk of recurrence aft...
31574/metabolismo, 31574/patología, Inhibidor p16 de la Quinasa Dependiente de Ciclina/biosíntesis, Antígeno Ki-67/biosíntesis, Clasificación del Tumor, Telomerasa/biosíntesis
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Expression of Ki-67 and P16 INK4a in chemically-induced perioral squamous cell carcinomas in mice

Alves, Ângela Valéria Farias; Ribeiro, Danielle Rodrigues; Lima, Sonia Oliveira; Reis, Francisco Prado; Soares, Andréa Ferreira; Gomes, Margarete Zanardo; Albuquerque Júnior, Ricardo Luiz Cavalcanti de.
Rev. Col. Bras. Cir; 43 (2), 2016
ABSTRACT Objective: to evaluate the influence of Ki-67 and P16INK4a proteins immunohistochemical expressions on the clinical and morphological parameters of perioral squamous cell carcinoma induced with 9,10-dimethyl-1,2-benzanthracene (DMBA) in mice. Methods: we topically induced the lesions in the or...
Carcinoma de Células Escamosas/inducido químicamente, Carcinoma de Células Escamosas/metabolismo, Inhibidor p16 de la Quinasa Dependiente de Ciclina/biosíntesis, Antígeno Ki-67/biosíntesis, Ratones, Neoplasias de la Boca/inducido químicamente, Neoplasias de la Boca/metabolismo, Neoplasias Experimentales/inducido químicamente, Neoplasias Experimentales/metabolismo
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p16INK 4a and Ki-67 expression in human papilloma virus-related head and neck mucosal lesions

Gültekin, Sibel Elif; Sengüven, Burcu; Klussmann, Jens Peter; Dienes, Hans Peter.
Invest. clín; 56 (1), 2015
Human papilloma virus (HPV) is postulated as a risk factor in the etiology of some specific mucosal pathologies in the head and neck regions. Despite the frequent use of p16INK4a as a surrogate marker for HPV-infection, there is still controversy with respect to its reliability. This study has been under...
Inhibidor p16 de la Quinasa Dependiente de Ciclina/biosíntesis, Neoplasias de Cabeza y Cuello/virología, Antígeno Ki-67/biosíntesis, Papillomaviridae/metabolismo, Neoplasias de Cabeza y Cuello/patología
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