LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The immunogenetics of multiple sclerosis. The frequency of HLA-alleles class 1 and 2 is lower in Southern Brazil than in the European population

ABSTRACT Objective To study the HLA of class 1and 2 in a multiple sclerosis (MS) population to verify the susceptibility for the disease in the Southern Brazil. Methods We analyzed patients with MS and controls, by direct sequencing of the genes related to HLA DRB1, DQB1, DPB1, A, B and C alleles wit...

Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population

Barbosa, Ângela Marques; Prestes-Carneiro, Luiz Euribel; Sobral, Aldri Roberta Sodoschi; Sakiyama, Marcelo Jun; Lemos, Bruna Cerávolo; Abreu, Marilda Aparecida Milanez Morgado de; Martos, Luciana Leite Crivelin; Moliterno, Ricardo Alberto.

An. bras. dermatol; 91 (3), 2016

Abstract: Background: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic. Studies linking Human Leukocyte Antigens (HLA) to AA have sugg...

Antígenos de Histocompatibilidad Clase II/genética, Antígenos de Histocompatibilidad Clase I/genética, Alopecia Areata/genética, Alopecia Areata/inmunología, Brasil, Estudios de Casos y Controles, Estudios Transversales, Población Blanca, Frecuencia de los Genes/genética, Antígenos HLA-B/sangre, Antígenos HLA-B/genética, Antígenos HLA-C/sangre, Antígenos HLA-C/genética, Cadenas HLA-DRB1/sangre, Cadenas HLA-DRB1/genética, Antígenos de Histocompatibilidad Clase I/sangre, Antígenos de Histocompatibilidad Clase II/sangre

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