Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1
Acta cir. bras; 34 (2), 2019
Abstract Purpose: To explore the effect of milk fat globule-epidermal growth factor 8 (MFG-E8) on sepsis-induced acute kidney injury (SAKI). Methods: Male C57BL/6 mice were randomized to control, sham, CLP, CLP+PBS, and CLP+rmMFG-E8 groups. SAKI was induced by cecal ligation and puncture (CLP). Recomb...
Lesión Renal Aguda/etiología, Lesión Renal Aguda/prevención & control, Antígenos de Superficie/uso terapéutico, Ratones Endogámicos C57BL, Proteínas de la Leche/uso terapéutico, FN-kappa B/antagonistas & inhibidores, Sustancias Protectoras/uso terapéutico, Sepsis/complicaciones, Transducción de Señal/efectos de los fármacos