LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Can diabetes mellitus modify the plasma concentrations of rifampicin in patients under treatment for tuberculosis?

Abstract Rifampicin is a key component of treatment for tuberculosis and its efficacy is determined by the blood levels attained after therapeutic doses. However, there is a high variability of rifampicin blood levels that is related to both the patient and the formulation used. To date, the effect of di...

Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis

Uchoa, Breno Kristoffer Beleza; Albério, Carlos Augusto Abreu; Pinto, Ana Carla Godinho; Lucena, Stefania de Medeiros Araujo; Vieira, José Luiz Fernandes.

Braz. j. infect. dis; 23 (2), 2019

ABSTRACT Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifam...

Antibióticos Antituberculosos/administración & dosificación, Antibióticos Antituberculosos/sangre, Cromatografía Líquida de Alta Presión, Relación Dosis-Respuesta a Droga, Pruebas de Sensibilidad Microbiana, Mycobacterium tuberculosis/efectos de los fármacos, Estudios Prospectivos, Valores de Referencia, Reproducibilidad de los Resultados, Rifampin/administración & dosificación, Rifampin/sangre, Esputo/efectos de los fármacos, Esputo/microbiología, Resultado del Tratamiento, Tuberculosis Pulmonar/sangre, Tuberculosis Pulmonar/tratamiento farmacológico

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