LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Atividade anticarcinogênica da tributirina associada ou não ao sorafenibe em ratos Fischer-344 implantados com células GP7TB

Tavares, Paulo Eduardo Latorre Martins.

O câncer primário de fígado (CPF) apresenta mau prognóstico, o que torna importante sua quimioprevenção. Nesse sentido, a tributirina (TB), um pró-fármaco do ácido butírico (AB), presente em laticínios e no mel, mostrou-se um agente quimiopreventivo promissor da hepatocarcinogênese experiment...

Cromatografía de Gases y Espectrometría de Masas/métodos, Neoplasias Hepáticas/prevención & control, Carcinoma Hepatocelular, Ácido Butírico/agonistas, Células Tumorales Cultivadas/clasificación, Inmunohistoquímica/métodos, Interpretación Estadística de Datos, Western Blotting/instrumentación, Preparaciones Farmacéuticas/análisis, Anticarcinógenos/análisis

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Complexation and enhancement of temozolomide solubility with cyclodextrins

Gürten, Berna; Yenigül, Elçin; Sezer, Ali Demir; Malta, Seyda.

Braz. J. Pharm. Sci. (Online); 54 (2), 2018

ABSTRACT Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide...

Preparaciones Farmacéuticas, Ciclodextrinas/efectos adversos, Anticarcinógenos/análisis, Microscopía Electrónica de Rastreo/métodos, Solubilidad

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Development and validation of a HPTLC method for analysis of Sunitinib malate

Hajmalek, Monireh; Goudarzi, Masoumeh; Ghaffari, Solmaz; Attar, Hossein; Mazlaghan, Mehrnoosh Ghanbari.

Braz. j. pharm. sci; 52 (4), 2016

ABSTRACT A simple high performance thin layer chromatography (HPTLC) has been developed and validated for determination of sunitinib malate and possible impurities. The samples were applied in forms of bands on an aluminum TLC plate pre-coated with silica gel and were separated using dichloromethane: met...

Estudio de Validación, Anticarcinógenos/análisis, Cromatografía/clasificación, Cromatografía Líquida de Alta Presión

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Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha, Swatantra Kumar Singh; Ghoshal, Saurav; Rai, Awani Kumar; Singh, Satyawan.

Braz. j. pharm. sci; 49 (4), 2013

Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation,...

Nanotubos de Carbono/análisis, Administración del Tratamiento Farmacológico, Neoplasias/clasificación, Anticarcinógenos/análisis, Nanotubos de Carbono/22074

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Differential susceptibilities of human lung, breast and skin cancer cell lines to killing by five sea anemone venoms

Ramezanpour, M; Burke da Silva, K; Sanderson, B. J.

J. venom. anim. toxins incl. trop. dis; 18 (2), 2012

Although sea anemones are well known for being rich sources of toxins, including cytolysins and neurotoxins, their venoms and toxins have been poorly studied. In the present study, the venoms from five sea anemones (Heteractis crispa, Heteractis magnifica, Heteractis malu, Cryptodendrum adhaesivum and En...

Anticarcinógenos/análisis, Neoplasias Pulmonares, Neoplasias Cutáneas, Neoplasias de la Mama, Anémonas de Mar, Venenos de Cnidarios

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