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Simultaneous Estimation and Validation of Four Antiepileptic Drugs from Bulk and Formulations Using Reverse Phase HPLC

Kole, Pooja; Parameswaran, Sandhya.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Epilepsy is a disorder of the central nervous system, in which the nerve cell activity in the brain is disturbed causing seizures. The objective was to develop an RP-HPLC method for consistent simultaneous quantitation of four antiepileptic drugs Levetiracetam (LVT), Lamotrigine (LTG), Phenobarb...
Anticonvulsivantes/análisis, Cromatografía de Fase Inversa/métodos, Epilepsia/patología, Preparaciones Farmacéuticas/análisis, d0024900
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Interchangeability among carbamazepine formulations: the impact over epilepsy patients

Frade, Virgínia Paula; Paiva, Maria José Nunes de; Martins, Isarita; Castro, Whocely Victor de; Belo, Vinícius Silva; Baldoni, André Oliveira; Lima, Priscila de Freitas; Sanches, Cristina.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract The treatment of epilepsy is complex and a matter of concern is the interchangeability among different formulations available for antiepileptic drugs. To evaluate the effects of interchangeability among carbamazepine formulations on patients with epilepsy. This is a prospective cohort study that...
Epilepsia/patología, Pacientes/clasificación, Intercambiabilidad de Medicamentos, Carbamazepina/efectos adversos, Anticonvulsivantes/análisis, Medicamentos Genéricos/análisis
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Influence of the clinical profile of patients with refractory epilepsy on lamotrigine plasma concentration

Baldoni, André Oliveira; Freitas-Lima, Priscila; Alexandre, Veriano; Ferreira, Flávia Isaura de Santi; Martinez, Edson Zangiacomi; Queiroz, Regina Helena Costa; Sakamoto, Americo Ceiki; Pereira, Leonardo Regis Leira.
Braz. J. Pharm. Sci. (Online); 54 (2), 2018
ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic ...
Anticonvulsivantes/análisis, Epilepsia Refractaria/tratamiento farmacológico, Interacciones Farmacológicas/inmunología, Quimioterapia/22074
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Interchangeability among therapeutic equivalents of lamotrigine: evaluation of quality of life

Girolineto, Beatriz Maria Pereira; Junior, Veriano Alexandre; Sakamoto, Américo Ceiki; Pereira, Leonardo Régis Leira.
Braz. j. pharm. sci; 48 (1), 2012
Epilepsy is the most common serious neurological disorder worldwide. Approximately 70% of patients with epilepsy have their seizures controlled by clinical and pharmacological treatment. This research evaluated the possible influence of interchangeability among therapeutic equivalents of LTG on the clini...
Equivalencia Terapéutica, Calidad de Vida, Epilepsia/prevención & control, Anticonvulsivantes/análisis, terapia
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