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A newly validated high-performance liquid chromatography method with diode array ultraviolet detection for analysis of the antimalarial drug primaquine in the blood plasma

Carmo, Ana Paula Barbosa do; Borborema, Manoella; Ribeiro, Stephan; De-Oliveira, Ana Cecilia Xavier; Paumgartten, Francisco Jose Roma; Moreira, Davyson de Lima.
Rev. Soc. Bras. Med. Trop; 50 (4), 2017
Abstract INTRODUCTION: Primaquine (PQ) diphosphate is an 8-aminoquinoline antimalarial drug with unique therapeutic properties. It is the only drug that prevents relapses of Plasmodium vivax or Plasmodium ovale infections. In this study, a fast, sensitive, cost-effective, and robust method for the extr...
Antimaláricos/sangre, Antimaláricos/farmacocinética, Cromatografía Líquida de Alta Presión, Ratones, Primaquina/sangre, Primaquina/farmacocinética, Espectrofotometría Ultravioleta
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Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria

Vieira, José Luiz Fernandes; Borges, Larissa Maria Guimarães; Ferreira, Michelle Valéria Dias; Rivera, Juan Gonzalo Bardarez; Gomes, Margarete do Socorro Mendonça.
Braz. j. infect. dis; 20 (5), 2016
Abstract Objective To evaluate whether patient age has a significant impact on mefloquine concentrations in the plasma and erythrocytes over the course of treatment for uncomplicated falciparum malaria. Methods A total of 20 children aged between 8 and 11 years and 20 adult males aged between 22 and 41...
Enfermedad Aguda, Factores de Edad, Antimaláricos/sangre, Cromatografía de Fase Inversa, Eritrocitos/efectos de los fármacos, Malaria Falciparum/sangre, Malaria Falciparum/tratamiento farmacológico, Mefloquina/sangre, Plasma, Valores de Referencia, Estadísticas no Paramétricas, Factores de Tiempo
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