Mammadov, Renad;
Suleyman, Bahadir;
Altuner, Durdu;
Demirci, Elif;
Cetin, Nihal;
Yilmaz, Adnan;
Baykal, Huseyin;
Alpcan, Hilal;
Turumtay, Emine Akyuz;
Suleyman, Halis.
Abstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esopha...
Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment. The potential mechanisms of cancer cell resistance to Taxol are not completely clear. It has been reported that micro...
Antineoplásicos Fitogénicos/metabolismo,
Antineoplásicos Fitogénicos/uso terapéutico,
Apoptosis/genética,
Autofagia/genética,
Neoplasias de la Mama/tratamiento farmacológico,
Neoplasias de la Mama/genética,
Neoplasias de la Mama/metabolismo,
Resistencia a Antineoplásicos/genética,
Regulación Neoplásica de la Expresión Génica/genética,
Proteína HMGB1/genética,
Proteína HMGB1/metabolismo,
Células MCF-7/metabolismo,
MicroARNs/genética,
MicroARNs/metabolismo,
Paclitaxel/metabolismo,
Paclitaxel/uso terapéutico,
Regulación hacia Arriba/genética
Summary Objective: The current study aimed to investigate the clinical efficacy of paclitaxel combined with avastin for non-small cell lung cancer (NSCLC) patients diagnosed with malignant pleural effusion (MPE). Method: Total of 33 patients diagnosed with NSCLC as well as malignant pleural effusion we...
Inhibidores de la Angiogénesis/efectos adversos,
Inhibidores de la Angiogénesis/uso terapéutico,
Antineoplásicos Fitogénicos/efectos adversos,
Antineoplásicos Fitogénicos/uso terapéutico,
Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos,
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico,
Bevacizumab/efectos adversos,
Bevacizumab/uso terapéutico,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Supervivencia sin Enfermedad,
Neoplasias Pulmonares/tratamiento farmacológico,
Persona de Mediana Edad,
Paclitaxel/efectos adversos,
Paclitaxel/uso terapéutico,
Derrame Pleural Maligno/tratamiento farmacológico,
Calidad de Vida,
Seguridad,
Análisis de Supervivencia,
Resultado del Tratamiento
Higher plants have provided various natural derived drugs used currently in western medicine. Tessaria absinthioides (Hook. & Arn.) DC, Asteraceae, is a native plant from South-America with reported ethnopharmacological and culinary uses. Despite recent scientific reports about plants properties, there i...
Antineoplásicos Fitogénicos/farmacología,
Antineoplásicos Fitogénicos/uso terapéutico,
Asteraceae/química,
Línea Celular Tumoral,
Neoplasias Colorrectales/tratamiento farmacológico,
Neoplasias Colorrectales/patología,
Modelos Animales de Enfermedad,
Fluorouracilo,
Ratones Endogámicos BALB C,
Extractos Vegetales/farmacología,
Extractos Vegetales/uso terapéutico,
Ratas Sprague-Dawley,
Sales de Tetrazolio,
Pruebas de Toxicidad
Introducción: la curcumina es el principal compuesto polifenólico bioactivo de la planta Curcuma longa. Esta molécula ha mostrado efectos antioxidantes, anti-inflamatorios y anticancerígenos en diferentes modelos experimentales. Como parte de su actividad benéfica en células tumorales, se le ha aso...
ABSTRACT A 69-year-old male patient, smoker, was diagnosed with small cell lung cancer metastatic to lung, liver and central nervous system. He received chemotherapy with carboplatin AUC 5 on day 1 and etoposide 100mg/m2 on days 1, 2 and 3. During the first cycle, the patient presented with febrile neutr...
Antineoplásicos Fitogénicos/efectos adversos,
Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico,
Etopósido/efectos adversos,
Neoplasias Pulmonares/tratamiento farmacológico,
Neumatosis Cistoide Intestinal/inducido químicamente,
Antineoplásicos Fitogénicos/uso terapéutico,
Carcinoma de Pulmón de Células no Pequeñas/secundario,
Etopósido/uso terapéutico,
Neoplasias Pulmonares/secundario,
Terapia por Inhalación de Oxígeno,
Neumatosis Cistoide Intestinal/terapia
Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the...
Several novel bioactive components isolated from Chinese medicinal plants will be presented. These include novel maytansinoid tumor, inhibitors, some new ent-kaurane and rosane diterpenoids from Mallotus anomalus Meer et Chun (Euphorbiaceae), as well asnovel insecticide, stemona alkaloids from Stemona pa...
