Results: 10

Eficácia e segurança de rotigotina, comparada a outros agonistas dopaminérgicos disponíveis no SUS, para o tratamento da doença de Parkinson: revisão rápida de evidências
Effectiveness and safety of rotigotine in comparison to other dopaminergic agonists available in the Brazilian Public Health System for treatment of Parkinson's disease: rapid evidence review

Rotigotina e outros medicamentos antiparkinsonianos, com ênfase em agonistas dopaminérgicos (bromocriptina e pramipexol). Indicação: Tratamento da doença de Parkinson. Pergunta: Há superioridade de eficácia e segurança da rotigotina, comparado aos agonistas dopaminérgicos disponíveis atualmente...

Coumarin analogue 3-methyl-7H-furo[3,2-g]chromen-7-one as a possible antiparkinsonian agent

Biomédica (Bogotá); 39 (3), 2019
Abstract Introduction: Parkinson's disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy. Several substituted coumarins have shown activity as inhibitors of monoamine oxidase B. ...

Deep brain stimulation in parkinson disease

The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the phy...

Motor and non-motor wearing-off and its impact in the quality of life of patients with Parkinson's disease

Arq. neuropsiquiatr; 76 (8), 2018
ABSTRACT The wearing-off phenomenon is common in patients with Parkinson's disease. Motor and non-motor symptoms can fluctuate in relation to the "on/off" periods. Objective: To assess the impact of motor and non-motor wearing-off on activities of daily living and quality of life of patients with PD. M...

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Arq. neuropsiquiatr; 76 (2), 2018
ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25,...

Impact of levodopa treatment in the voice pattern of Parkinson's disease patients: a systematic review and meta-analysis

CoDAS; 30 (5), 2018
Abstract Purpose Investigate the association between levodopa therapy and vocal characteristics in Parkinson's disease patients. Search strategy Studies published at MEDLINE, LILACS, and SciELO, from 1960 to December 2016. A systematic review and meta-analysis was performed using the following keywor...

Harbinger of storm: influence of Oliver Sacks on levodopa therapy in early 1970s

Arq. neuropsiquiatr; 74 (8), 2016
ABSTRACT Most known by his literary ability, the words of the neurologist Oliver Sacks (1933-2015) also had an impact on scientific community about the role of levodopa on parkinsonisms. Different from the most authors and based on his experience described on the book “Awakenings”, he had a p...

Disautonomia na doença de Parkinson. Revisão da literatura

Rev. bras. neurol; 47 (4), 2011
Desde o trabalho original, são conhecidos alguns distúrbios autonômicos associados à doença de Parkinson, tais como, sialorréia, disfagia e constipação intestinal. Nesta revisão, descrevemos as principais alterações gastrointestinais, cardiovasculares, urinárias, sexuais, termorregulatórias ...