Background: Micrurus mipartitus is a coral snake of public health concern in Colombia. Its venom is mainly composed of three-finger toxins (3FTxs), Mipartoxin-1 being the most abundant protein partially responsible for its lethal effect. In this work, we present the production of Mipartoxin-1 in a recomb...
Abstract Snakebite envenoming is a significant global health challenge, and for over a century, traditional plasma-derived antivenoms from hyperimmunized animals have been the primary treatment against this infliction. However, these antivenoms have several inherent limitations, including the risk of cau...
Yoshida, Edson Hideaki;
Dini, Murilo Melo Juste;
Oliveira, Isadora Caruso Fontana;
Matiello Filho, José Antonio;
Cogo, José Carlos;
Cruz-Hofling, Maria Aliceda;
Grotto, Denise;
Hyslop, Stephen;
Yoshida, Valquíria Miwa Hanai;
Oshima, Franco Yoko.
Abstract Acute kidney injury (AKI) is the major cause of mortality following bites by the South American rattlesnake Crotalus durissus terrificus. We investigated the early onset of Crotalus durissus terrificus venom-induced AKI in rats within 2 h of venom injection and its attenuation by antivenom. Seve...
Abstract Snakebite is one of the major health issues posing considerable morbidity and mortality. According to an estimate of World Health Organization (WHO) (World health organization, 2021) approximately 5 million people are bitten by several species of snakes resulting in up to 2.5 million envenomatio...
There are few scientific studies that explore the use of medicinal plants for snakebite envenoming in Central America, although plant-based therapies have been traditionally used in the region. This work reviews the studies conducted in Central America to assess the ability of extracts obtained from plan...
Introducción: En el Perú, los accidentes ofídicos son un importante problema de salud pública, debido a una amplia distribución territorial de diferentes tipos de serpientes. Objetivo: Describir las características clínico - epidemiológicas y el manejo de los accidentes ofídicos registrados en...
Saravia-Otten, Patricia;
Hernández, Rosario;
Marroquín, Nereida;
García, Gabriela;
Nave, Federico;
Rochac, Lorena;
Genovez, Vicente;
Mérida, Max;
Cruz, Sully M;
Cáceres, Armando;
Gutiérrez, Jose M.
Neurolaena lobata es utilizada tradicionalmente en Centroamérica para tratar la mordedura de serpiente, pero su efectividad para contrarrestar el envenenamiento producido por Bothrops asper ha sido poco estudiada. Se evaluó la capacidad del extracto etanólico de sus hojas para inhibir las actividades ...
Bothrops,
Mordeduras de Serpientes/tratamiento farmacológico,
Extractos Vegetales/farmacología,
Antivenenos/farmacología,
Venenos de Crotálidos/antagonistas & inhibidores,
Inhibidores de Fosfolipasa A2/farmacología,
Extractos Vegetales/uso terapéutico,
Plantas Medicinales,
Guatemala,
Medicina Tradicional,
Proteolisis/efectos de los fármacos,
Coagulación Sanguínea/efectos de los fármacos,
Extractos Vegetales/química,
Hojas de la Planta,
Etanol/uso terapéutico,
Electroforesis en Gel de Poliacrilamida
In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases. The available bothropic antivenoms are efficient in avoiding fatalities, but do not completely neutralize venom serine protease...
Abstract We present a case of human intoxication due to a snakebite by the opisthoglyphous dipsadid Thamnodynastes lanei. A 26-year-old man was bitten on the right hand and was not medicated. Bleeding lasted a few seconds, while paresthesia, chills, and headache persisted for up to 10 hours. The pain dis...
Silva, Flavio Souza;
Ibiapina, Hiochelson Najibe Santos;
Neves, Juliana Costa Ferreira;
Coelho, Kerolaine Fonseca;
Barbosa, Fabiane Bianca Albuquerque;
Lacerda, Marcus Vinicius Guimarães;
Sachett, Jacqueline Almeida Gonçalves;
Malheiro, Adriana;
Monteiro, Wuelton Marcelo;
Costa, Allyson Guimarães.
Abstract INTRODUCTION: Snakebites in the Brazilian Amazon are caused mostly by snakes from the Bothrops genus and envenomated patients may suffer from tissue complications. METHODS: This study aimed to identify risk factors for severe tissue complications (STC) in patients with Bothrops snakebite in t...
