SUMMARY: An association between certain food additives and chronic diseases is reported. Current study determined whether administering toxic doses of the food additive monosodium glutamate (MSG) into rats can induce aortopathy in association with the oxidative stress and inflammatory biomarkers upregula...
The Gαq-RGS2 loop activator, 1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)-phenyl)-1H-1,2,4-triazol-5(4H)-one has demonstrated Gαq signaling inhibitor activity. Therefore, we aimed to study the effect of Gαq-RGS2 loop activator on isolated heart and aorta of normal rats. Heart and aorta were iso...
Excessive consumption of carbohydrate and fat increases the risk of cardiovascular disease. We sought to determine the potential ultrastructural alterations in large blood vessels induced by a high fat and fructose diet (HFD) in a rat model of prediabetes. Rats were either fed with HFD (model group) or a...
Summary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with patholo...
O comportamento do pericárdio bovino, preservado em glutaraldeído, na confecçäo de prótese valvulares é bem conhecido. Embora amplamente empregado na forma de retalho, foi pouco estudado neste sentido. Com esta finalidade, 21 caes foram submetidos ao implante cirúrgico de um retalho padronizado de...
A ectasia ânulo-aórtica é lesao cujo tratamento preferencial compreende a substituiçao da aorta ascendente dilatada por tubo sintético, acompanhada da substituiçao da valva aórtica. Essa substituiçao geralmente ocorre pela disfunçao da valva graças à dilataçao do anel e a prótese empregada n...
