Results: 2

Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice

Acta cir. bras; 33 (11), 2018
Abstract Purpose: To determine whether the absence of transglutaminase 2 enzyme (TG2) in TG2 knockout mice (TG2-/-) protect them against early age-related functional and histological arterial changes. Methods: Pulse wave velocity (PWV) was measured using non-invasive Doppler and mean arterial pressure...

Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation

Braz. j. med. biol. res; 49 (7), 2016
Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism. Here, we investigated the role of βAR subtypes (β1AR, β2AR, and β3AR) and cAMP in maturation-dependent vasorelaxat...