Results: 8

Interaction between physical exercise and APOE gene polymorphism on cognitive function in older people

Colovati, M E S; Novais, I P; Zampol, M; Mendes, G D; Cernach, M C S; Zanesco, A.

Braz. j. med. biol. res; 54 (2), 2021

We aimed to present an overview of the literature regarding the interaction between physical exercise and APOE gene polymorphism on cognitive function, particularly in patients with Alzheimer's disease (AD). Firstly, this review focused on the effect of the physical exercise on cognitive function, regard...

Alelos, Enfermedad de Alzheimer/genética, Apolipoproteínas E/genética, Cognición, Ejercicio Físico, Genotipo, Polimorfismo Genético, Calidad de Vida

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Inhibition of CXCR2 alleviates the development of abdominal aortic aneurysm in Apo E-/- mice

Sun, Bo; Li, Fangda; Lai, Song; Zhang, Xu; Wang, Hongxia; Li, Yuan; Wang, Wei; Chen, Yuexin; Liu, Bao; Zheng, Yuehong.

Acta cir. bras; 36 (1), 2021

ABSTRACT Purpose To investigate the relationship between atherosclerotic abdominal aortic aneurysm (AAA) and CXC chemokine receptor type 2 (CXCR2). Methods Mouse AAA model was established by embedding angiotensin-II pump (1000 ng/kg/min) in ApoE-/- mice. Mice were received SB225002, a selective CXCR2 a...

Angiotensina II, Aneurisma de la Aorta Abdominal/tratamiento farmacológico, Aneurisma de la Aorta Abdominal/prevención & control, Apolipoproteínas E/genética, Modelos Animales de Enfermedad, Macrófagos, Ratones Endogámicos C57BL, Receptores de Interleucina-8B

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Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice

Zhao, Ruifeng; Xiao, Hanyan; Jin, Tao; Xu, Feng; Li, Yan; Li, Haiyan; Zhang, Zhouyi; Zhang, Yan.

Braz. j. med. biol. res; 54 (4), 2021

Naringenin (NAR) is a major flavanone in citrus fruits that has multiple pharmacological attributes such as anticancer and antiatherogenic. This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS...

Apolipoproteínas E/genética, Aterosclerosis/tratamiento farmacológico, Autofagia, Flavanonas/farmacología

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Phenotype of definite familial hypercholesterolemia with negative genetic study in Argentina

Corral, Pablo; Bañares, Virginia; Sáenz, Benjamín; Zago, Valeria; Sarobe, Agustina; López, Graciela; Berg, Gabriela; Schreier, Laura.

Arch. cardiol. Méx; 90 (2), 2020

Abstract Objective: Familial hypercholesterolemia (FH) is a monogenic disease, associated with variants in the LDLR, APOB and PCSK9 genes. The initial diagnosis is based on clinical criteria like the DLCN criteria. A score > 8 points qualifies the patient as "definite" for FH diagnosis. The detection...

Apolipoproteína B-100/genética, Apolipoproteínas E/genética, Argentina, Variación Genética, Hiperlipoproteinemia Tipo II/genética, Mutación, Fenotipo, Polimorfismo de Nucleótido Simple, Proproteína Convertasa 9/genética, Receptores de LDL/genética

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Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review

Cambruzzi, Eduardo; Pêgas, Karla Lais.

J. bras. nefrol; 41 (3), 2019

Abstract Lipoprotein glomerulopathy (LPG) is an uncommon cause of nephrotic syndrome and/or kidney failure. At microscopy, LPG is characterized by the presence of lipoprotein thrombi in dilated glomerular capillaries due to different ApoE mutations. ApoE gene is located on chromosome 19q13.2, and can be ...

Apolipoproteínas E/genética, Hipolipemiantes/uso terapéutico, Enfermedades Renales/complicaciones, Enfermedades Renales/genética, Enfermedades Renales/patología, Enfermedades Renales/terapia, Fallo Renal Crónico/etiología, Fallo Renal Crónico/cirugía, Trasplante de Riñón, Mutación, Factores Sexuales, Resultado del Tratamiento

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OxLDL plasma levels in patients with Alzheimer's disease

Grossi, Marina Felipe; Carvalho, Maria das Graças; Silveira, Josianne Nicácio; Gonçalves, Gisele Santos; Gomes, Karina Braga; Bicalho, Maria Aparecida; Silva, Ieda de Fátima Oliveira.

Arq. neuropsiquiatr; 76 (4), 2018

ABSTRACT Objective: The objective of this study was to characterize the conventional lipid profile, oxLDL levels and ApoE polymorphism in patients with Alzheimer's disease (AD) and in elderly individuals without cognitive impairment. Methods: Eighty elderly individuals were selected and the levels of o...

Enfermedad de Alzheimer/sangre, Enfermedad de Alzheimer/genética, Apolipoproteínas E/genética, Estudios de Casos y Controles, Ensayo de Inmunoadsorción Enzimática, Lípidos/sangre, Lipoproteínas LDL/sangre, Reacción en Cadena de la Polimerasa, Polimorfismo Genético/genética, Polimorfismo de Longitud del Fragmento de Restricción

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Interaction between polymorphisms in SLC6A4 and BDNF on major depressive disorder in a sample of the argentinean population

Bassi, Sabrina; Costa, Lucas; Lesik, Laura; Faccioli, José Luis; Finkelssztein, Carlos; Cajal, Andrea.

Rev. Hosp. Ital. B. Aires (2004); 38 (1), 2018

The dysfunction in the serotoninergic neurotransmission has been classically associated with major depressive disorder (MDD); however, other pathways and processes seem to have a role in this illness, such as neurogenesis and related molecules: the Brain-Derived Neurotrophic Factor (BDNF) and the Apolipo...

Polimorfismo Genético, Argentina/epidemiología, Trastorno Depresivo Mayor/genética, Proteínas de Transporte de Serotonina en la Membrana Plasmática/deficiencia, Proteínas de Transporte de Serotonina en la Membrana Plasmática/genética, Factor Neurotrófico Derivado del Encéfalo/deficiencia, Factor Neurotrófico Derivado del Encéfalo/genética, Apolipoproteínas E/deficiencia, Apolipoproteínas E/genética, Receptores de Serotonina 5-HT2/deficiencia, Receptores de Serotonina 5-HT2/genética, Trastorno Depresivo Mayor/patología

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Associations of Cerebrovascular Metabolism Genotypes With Neuropsychiatric Symptoms and Age at Onset of Alzheimer's Disease Dementia

Oliveira, Fabricio F de; Chen, Elizabeth S; Smith, Marilia C; Bertolucci, Paulo H.

Braz. J. Psychiatry (São Paulo, 1999, Impr.); 39 (2), 2017

Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer’s disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia ons...

Edad de Inicio, Alelos, Enfermedad de Alzheimer/genética, Enfermedad de Alzheimer/metabolismo, Enfermedad de Alzheimer/fisiopatología, Apolipoproteínas E/genética, Trastornos Cerebrovasculares/genética, Trastornos Cerebrovasculares/metabolismo, Trastornos Cerebrovasculares/fisiopatología, Proteínas de Transferencia de Ésteres de Colesterol/genética, Estudios Transversales, Dosificación de Gen, Estudios de Asociación Genética, Genotipo, Enfermedades de Inicio Tardío, Modelos Lineales, Lipoproteínas LDL/genética, Receptores X del Hígado/genética, Pruebas Neuropsicológicas

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