Zhang, Xiaojun;
Wang, Changsen;
Xu, Hao;
Cai, Shuyun;
Liu, Keyu;
Li, Simeng;
Chen, Linming;
Shen, Siman;
Gu, Xiaoxia;
Tang, Jing;
Xia, Zhengyuan;
Hu, Zhe;
Ma, Xiaotang;
Zhang, Liangqing.
BACKGROUND: Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-induced injury in human umbilical vein endothelial cells (HUVECs) and that microvesicle...
Previously, we evaluated the effect of trichostatin A (TSA) on the expression of DNA methyltransferase 1 (DNMT1) in Hepatocellular Carcinoma (HCC). Fragile histidine triad (FHIT) and WW domain-containing oxidoreductase (WWOX) are two of the most common down-regulated genes in many cancers located on chro...
Abstract Background: Acute lymphoblastic leukemia (ALL) is an aggressive malignant disease with high prevalence in pediatric patients. It has been shown that the downregulation of Fas expression is correlated with an inadequate response in ALL, although these mechanisms are still not well understood. Se...
Apoptosis/fisiología,
Hipoxia de la Célula/fisiología,
Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo,
Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo,
Factor de Transcripción YY1/metabolismo,
Receptor fas/metabolismo,
Caspasa 3/metabolismo,
Línea Celular Tumoral,
Regulación hacia Abajo,
Expresión Génica,
Subunidad alfa del Factor 1 Inducible por Hipoxia/genética,
Evasión Inmune,
Vigilancia Inmunológica,
Leucemia-Linfoma Linfoblástico de Células Precursoras/inmunología,
Leucemia-Linfoma Linfoblástico de Células Precursoras/patología,
Hipoxia Tumoral/fisiología,
Factor de Transcripción YY1/genética,
Receptor fasFelodipino
Opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is one kind of cytoplasmic long non-coding RNA (lncRNA), which has been demonstrated to play a critical function in multiple cancers. However, the detailed mechanism of OIP5-AS1 in the regulation of cervical cancer progression is still obscure. ...
Apoptosis/genética,
Apoptosis/fisiología,
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular/genética,
Proliferación Celular/fisiología,
Regulación Neoplásica de la Expresión Génica,
MicroARNs/genética,
MicroARNs/metabolismo,
ARN Largo no Codificante/genética,
ARN Largo no Codificante/metabolismo,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Regulación hacia Arriba,
Neoplasias del Cuello Uterino/metabolismo,
Neoplasias del Cuello Uterino/patología,
Quinasas Asociadas a rho/genética,
Quinasas Asociadas a rho/metabolismo
BACKGROUND Viruses can modulate intracellular signalling pathways to complete their infectious cycle. Among these, the PI3K/Akt pathway allows prolonged survival of infected cells that favours viral replication. GSK3β, a protein kinase downstream of PI3K/Akt, gets inactivated upon activation of the...
Aedes/citología,
Apoptosis/fisiología,
Western Blotting,
Línea Celular Tumoral,
Virus del Dengue/enzimología,
Glucógeno Sintasa Quinasas/antagonistas & inhibidores,
Glucógeno Sintasa Quinasas/fisiología,
Microscopía Fluorescente,
Fosforilación/fisiología,
Transducción de Señal,
Replicación Viral/fisiología
Ischemic heart disease (IHD) is one of the leading causes of death worldwide. C-type lectin domain family 3 member B (CLEC3B) is a C-type lectin superfamily member and is reported to promote tissue remodeling. The serum levels of CLEC3B are downregulated in patients with cardiovascular disease. However, ...
BACKGROUND: Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenes...
Apoptosis/fisiología,
Autofagia/fisiología,
MicroARNs/metabolismo,
Osteoartritis/metabolismo,
ARN Largo no Codificante/metabolismo,
Ubiquitina-Proteína Ligasas/metabolismo,
Apoptosis/genética,
Autofagia/genética,
MicroARNs/genética,
Osteoartritis/genética,
ARN Largo no Codificante/genética,
Ubiquitina-Proteína Ligasas/genética,
Western Blotting,
Proliferación Celular,
Regulación hacia Abajo,
Ensayo de Inmunoadsorción Enzimática,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Regulación hacia Arriba
Cancer is a multifactorial disease that constitutes a serious public health problem worldwide. Prostate cancer advanced stages are associated with the development of androgen-independent tumors and an apoptosis-resistant phenotype that progresses to metastasis. By studying androgen-independent lymphoid n...
Apoptosis/fisiología,
Proteínas Reguladoras de la Apoptosis/aislamiento & purificación,
Proteínas Reguladoras de la Apoptosis/metabolismo,
Células CHO,
Calcio/metabolismo,
Canales de Calcio/metabolismo,
Cricetulus,
ADN Complementario/aislamiento & purificación,
Óvulo/metabolismo,
Neoplasias de la Próstata/metabolismo,
Neoplasias de la Próstata/patología,
ARN Mensajero/metabolismo,
Xenopus laevis
BACKGROUND: Recent evidences indicated that some local anaesthetic agents played a role in inhibiting the proliferation of cancer cells; Whether ropivacaine is able to promote apoptosis of hepatocellular carcinoma (HCC) cells is still unclear. The aim of this study was to investigate the effect of ropiva...
Anestésicos Locales/farmacología,
Apoptosis/efectos de los fármacos,
Carcinoma Hepatocelular/patología,
Caspasa 3/metabolismo,
Neoplasias Hepáticas/patología,
Ropivacaína/farmacología,
Apoptosis/fisiología,
Carcinoma Hepatocelular/metabolismo,
Proliferación Celular/efectos de los fármacos,
Neoplasias Hepáticas/metabolismo,
Mitocondrias/efectos de los fármacos,
Transducción de Señal/efectos de los fármacos,
Línea Celular Tumoral,
Citometría de Flujo,
Microscopía Confocal,
Microscopía Fluorescente
