SUMMARY: We evaluated the role and mechanism of acteoside in the regulation of memory impairment induced by chronic unpredictable mild stress (CUMS). CUMS was used to induce depression in rats and the successful establishment of CUMS model were verified by forced swimming test and sucrose preference test...
Estrés Psicológico/complicaciones,
Trastornos de la Memoria/tratamiento farmacológico,
Glucósidos/administración & dosificación,
Glucósidos/uso terapéutico,
Polifenoles/administración & dosificación,
Polifenoles/uso terapéutico,
Reconocimiento en Psicología/efectos de los fármacos,
Plasticidad Neuronal/efectos de los fármacos,
Serina-Treonina Quinasas TOR/antagonistas & inhibidores,
Depresión/tratamiento farmacológico,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Escala de Evaluación de la Conducta,
Neuronas,
Técnica del Anticuerpo Fluorescente,
Western Blotting,
Aprendizaje por Laberinto,
Inhibidores mTOR
HIGHLIGHTS: Tumor progression and anxiety and depression behaviors under evaluation during propranolol use in murine melanoma. Evaluation of anxiety and depression through forced swimming behavior tests, elevated plus maze, open field and marble-burying test....
Fetal exposure to sevoflurane induces long-term cognitive impairment. Histone acetylation regulates the transcription of genes involved in memory formation. We investigated whether sevoflurane exposure during late-pregnancy induces neurocognitive impairment in offspring, and if this is related to histone...
Abstract The high prevalence of anxiety disorders associated with pharmacotherapy side effects have motivated the search for new pharmacological agents. Species from Citrus genus, such as Citrus limon (sicilian lemon), have been used in folk medicine as a potential therapy to minimize emotional disorders...
Abstract Hippocampus is a part of the brain that has a major role in spatial learning and memory which can be affected by herbal extracts. Incense resin (Styrax benzoin) has been used by local communities to improve intelligence. However, there is no scientific evidence of the functions of Styrax benzoin...
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. The therapeutic effect and underlying mechanism of ORC in vascular dementia (VaD) treatment remain unknown. In this study, 3-month-old male Sprague-Dawley rats with permanent bilateral common carotid artery...
Apoptosis/efectos de los fármacos,
Autofagia/efectos de los fármacos,
Disfunción Cognitiva/tratamiento farmacológico,
Disfunción Cognitiva/metabolismo,
Disfunción Cognitiva/fisiopatología,
Demencia Vascular/tratamiento farmacológico,
Demencia Vascular/metabolismo,
Demencia Vascular/fisiopatología,
Modelos Animales de Enfermedad,
Aprendizaje por Laberinto/efectos de los fármacos,
Fármacos Neuroprotectores/administración & dosificación,
Proteínas Proto-Oncogénicas c-akt/metabolismo,
Pirrolidinas/administración & dosificación,
Ratas Sprague-Dawley,
Transducción de Señal/fisiología,
Serina-Treonina Quinasas TOR/metabolismo
Few behavioral tests allow measuring several characteristics and most require training, complex analyses, and/or are time-consuming. We present an apparatus based on rat exploratory behavior. Composed of three different environments, it allows the assessment of more than one behavioral characteristic in ...
Ansiolíticos/farmacología,
Antidepresivos Tricíclicos/farmacología,
Ansiedad/psicología,
Apomorfina/farmacología,
Conducta Animal/efectos de los fármacos,
Conducta Animal/fisiología,
Investigación Conductal/instrumentación,
Clordiazepóxido/farmacología,
Agonistas de Dopamina/farmacología,
Conducta Exploratoria/efectos de los fármacos,
Conducta Exploratoria/fisiología,
Miedo/efectos de los fármacos,
Miedo/fisiología,
Antagonistas del GABA/farmacología,
Conducta Impulsiva/efectos de los fármacos,
Conducta Impulsiva/fisiología,
Aprendizaje por Laberinto/efectos de los fármacos,
Factores de Tiempo,
Ratas Wistar
Abstract Purpose To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia. Methods Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats i...
Alcaloides/farmacología,
Anestesia/efectos adversos,
Anestésicos por Inhalación/efectos adversos,
Ensayo de Inmunoadsorción Enzimática,
Hipocampo/efectos de los fármacos,
Hipocampo/metabolismo,
Interleucina-1beta/análisis,
Interleucina-6/análisis,
Isoflurano/efectos adversos,
Aprendizaje por Laberinto,
Factores de Crecimiento Nervioso/análisis,
Factores de Crecimiento Nervioso/efectos de los fármacos,
Fármacos Neuroprotectores/farmacología,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Reproducibilidad de los Resultados,
Sesquiterpenos/farmacología
Abstract We evaluated the involvement of the serotonergic system on memory formation and learning processes in healthy adults Wistar rats. Fifty-seven rats of 5 groups had one serotonergic nuclei damaged by an electric current. Electrolytic lesion was carried out using a continuous current of 2mA during ...
Conducta Animal,
Modelos Animales de Enfermedad,
Hipocampo/lesiones,
Hipocampo/fisiopatología,
Aprendizaje,
Aprendizaje por Laberinto,
Memoria,
Trastornos de la Memoria/fisiopatología,
Plasticidad Neuronal,
Ratas Wistar,
Neuronas Serotoninérgicas
Unbalanced nutrition during perinatal period causes varying degrees of perturbations in the metabolism and cognitive functions of offspring. The aim of this study was to investigate effects of maternal and postweaning high-fat diet (HFD) exposure on the growth parameters, hippocampal functions and morpho...
