Suppression of L-arginine-induced acute necrotizing pancreatitis in rats by metformin associated with the inhibition of myeloperoxidase and activation of interleukin-10
Int. j. morphol; 39 (1), 2021
SUMMARY: Acute pancreatitis is a frequent life-threatening inflammatory disease of the pancreas characterized by severe abdominal pain that lasts for days to weeks. We sought to determine whether the antidiabetic and anti-inflammatory drug, metformin can substantially protect against acute pancreatitis i...
Pancreatitis Aguda Necrotizante/tratamiento farmacológico, Pancreatitis Aguda Necrotizante/inducido químicamente, Arginina/toxicidad, Metformina/administración & dosificación, Peroxidasa/antagonistas & inhibidores, Interleucina-10/metabolismo, Modelos Animales de Enfermedad, Interleucina-10, Ratas Wistar, Páncreas/efectos de los fármacos, Sustancias Protectoras, L-Lactato Deshidrogenasa/antagonistas & inhibidores, Factor de Necrosis Tumoral alfa/antagonistas & inhibidores