LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells

Xiong, Xilin; Li, Yang; Liu, Ling; Qi, Kai; Chen, Yueqin; Fang, Jianpei; Zhang, Chi.

Biol. Res; 51 (), 2018

BACKGROUND: Arsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor (Trk) family comprises three members, namely TrkA, TrkB and TrkC. Various studies...

Arsenicales/farmacología, Puntos de Control del Ciclo Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Regulación Neoplásica de la Expresión Génica/efectos de los fármacos, Glicoproteínas de Membrana/efectos de los fármacos, Neuroblastoma/metabolismo, Óxidos/farmacología, Receptor trkB/efectos de los fármacos, Línea Celular Tumoral/efectos de los fármacos, Línea Celular Tumoral/metabolismo, Glicoproteínas de Membrana/metabolismo, Neuroblastoma/patología, Receptor trkB/metabolismo, Trióxido de Arsénico

Fulltext

Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent

Realgar is a naturally occurring arsenic sulfide (or Xionghuang, in Chinese). It contains over 90% tetra-arsenic tetrasulfide (As4S4). Currently, realgar has been confirmed the antitumor activities, both in vitro and in vivo, of realgar extracted using Acidithiobacillus ferrooxidans (A. ferrooxidans). Bi...