Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142
Braz. j. med. biol. res; 52 (5), 2019
The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qR...
Antineoplásicos/farmacología, Antineoplásicos/uso terapéutico, Apoptosis, Artesunato/farmacología, Artesunato/uso terapéutico, Linfocitos T CD4-Positivos/citología, Linfocitos T CD4-Positivos/efectos de los fármacos, Diferenciación Celular, Regulación hacia Abajo, Citometría de Flujo, Ratones Endogámicos C57BL, MicroARNs/metabolismo, Neoplasias Ováricas/tratamiento farmacológico, Neoplasias Ováricas/inmunología, Células TH1/citología, Células TH1/efectos de los fármacos