Many medications and vaccines have had implications in the development of musculoskeletal and joint symptoms, and among them the use of retinoids has been associated with the development of musculoskeletal symptoms, as well as axial symptoms suggestive of spondyloarthritis, with sacroiliitis, and to a le...
Abstract To explore the effects and mechanisms of benzoylaconitine and paeoniflorin on collagen-induced arthritis (CIA) rats. Weight, paw swelling, arthritis index and joint pathologic changes were examined in each group after CIA induction. PGE2, IL-1β, IL-6, IL-10, TNF-α, VEGF, MMP-3, IgG and anti-CI...
SUMMARY: Rheumatoid arthritis (RA) is considered an autoimmune disease distinguished by chronic synovial membrane inflammation, degraded cartilage, as well as bone destruction, which lead to joints pain and stiffness. The pathogenesis of RA involved at least two mechanisms: Cellular proliferation and act...
Tiadiazoles/administración & dosificación,
Tiadiazoles/farmacología,
Artritis Experimental/tratamiento farmacológico,
Artritis Reumatoide/tratamiento farmacológico,
Colágeno Tipo II/efectos adversos,
Apoptosis,
Inflamación,
Ratas Wistar,
Modelos Animales de Enfermedad,
Interleucina-1beta,
Inmunohistoquímica,
Western Blotting
This study investigated the repercussions of adjuvant-induced arthritis (AIA) on body composition and the structural organization of the soleus and cardiac muscles, including their vascularization, at different times of disease manifestation. Male rats were submitted to AIA induction by intradermal admin...
Rheumatoid arthritis (RA) is an autoimmune disease of knee joints involving pain and inflammation. Rhoifolin is a plant flavonoid known to have antioxidant and anti-inflammatory properties. This study was taken to identify the effect of rhoifolin on complete Freund's adjuvant (CFA)-induced arthritis in t...
Artritis Experimental/tratamiento farmacológico,
Artritis Experimental/metabolismo,
Artritis Reumatoide/tratamiento farmacológico,
Artritis Reumatoide/metabolismo,
Biomarcadores/sangre,
Citocinas/sangre,
Disacáridos/administración & dosificación,
Flavonoides/administración & dosificación,
Adyuvante de Freund/administración & dosificación,
Glicósidos/administración & dosificación,
Interleucina-1beta/sangre,
Interleucina-6/sangre,
FN-kappa B/efectos de los fármacos,
FN-kappa B/metabolismo,
Estrés Oxidativo/efectos de los fármacos,
Factor de Necrosis Tumoral alfa/sangre
This study aimed to analyze the antiarthritic activity of ginkgolic acid against the Complete Freund’s Adjuvant (CFA)-induced arthritis in rats. Arthritis was induced through an intradermal injection of CFA (0.1 mL) at the right hind footpad of adult Wistar Albino rats. Ginkgolic acid was administered ...
BACKGROUND: Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes In adjuvant arthritis rats but the subcellular mechanism remains unclear. Since ER stress, mitochondrial dysfunction and oxidative stress were involved in the effects of resveratrol with imbalance of calcium bio...
Apoptosis/efectos de los fármacos,
Artritis Experimental/fisiopatología,
Canales de Calcio/efectos de los fármacos,
Fibroblastos/efectos de los fármacos,
Proteína ORAI1/efectos de los fármacos,
Resveratrol/farmacología,
Molécula de Interacción Estromal 1/efectos de los fármacos,
Sinoviocitos/efectos de los fármacos,
Canales de Calcio/fisiología,
Mitocondrias/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Resveratrol/administración & dosificación
Abstract INTRODUCTION: Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats. METHODS: Rats were randomly allocated to eith...
Arthritis is positively associated with the decline of sex hormones, especially estrogen. Tamoxifen (TMX) is a selective estrogen receptor modulator, possessing agonist or antagonistic activity in different tissues. Thus, the objective of this study was to investigate the effect of TMX on the zymosan-ind...
Artritis Experimental/tratamiento farmacológico,
Ensayos de Migración de Leucocitos,
Movimiento Celular/efectos de los fármacos,
Modelos Animales de Enfermedad,
Antagonistas de Estrógenos/farmacología,
Ciclo Estral/efectos de los fármacos,
Neutrófilos/efectos de los fármacos,
Tamaño de los Órganos/efectos de los fármacos,
Ovariectomía,
Moduladores Selectivos de los Receptores de Estrógeno/farmacología,
Tamoxifeno/farmacología,
Factores de Tiempo,
Resultado del Tratamiento,
Útero/efectos de los fármacos,
Zimosan
Simone, Emilio De;
Lastra, Yael;
Caggiano, Nicolás;
Díaz, Julieta;
Rubatino, Florencia;
Ferretto, Araceli;
Sarobe, Verónica De Luca;
Gullace, Federico;
Ritacco, Elisabet;
Chiappe Barbará, Angelina.
Resumen Objetivo: Comparar y caracterizar modelos de osteoartritis inducida en ratas en una fase temprana (7 días luego de la inducción). Materiales y métodos: Este es un estudio retrospectivo que compara resultados de experiencias previas. Se compararon los modelos de: a) corte del ligamento cruz...
