Enhanced production of glutaminase-free L-asparaginase by marine Bacillus velezensis and cytotoxic activity against breast cancer cell lines
Electron. j. biotechnol; 42 (), 2019
Background: The increasing rate of breast cancer globally requires extraordinary efforts to discover new effective sources of chemotherapy with fewer side effects. Glutaminase-free L-asparaginase is a vital chemotherapeutic agent for various tumor malignancies. Microorganisms from extreme sources, such a...
Bacillus/enzimología, Glutaminasa/metabolismo, Asparaginasa/metabolismo, Neoplasias de la Mama/metabolismo, Neoplasias de la Mama/tratamiento farmacológico, Células Inmovilizadas, Fermentación, Células MCF-7, Asparaginasa/biosíntesis, Pruebas de Enzimas, Cinética, Concentración de Iones de Hidrógeno, Temperatura