Results: 92

Prospective Protective Effects of Arthrospira platensis Against Acetaminophen Induced Hepato-Renal Toxicity in Rats

Int. j. morphol; 41 (3), 2023
SUMMARY: The toxic effects of acetaminophen appear primarily in the liver and kidney. The protective effect of blue green alga Arthrospira platensis on hepato-renal toxicity caused by acetaminophen was evaluated in male rats. The obtained results showed that subcutaneous injection of acetaminophen at a d...

Tocilizumab en pacientes COVID-19: evaluación del perfil de seguridad en una indicación off label

Rev. méd. Chile; 150 (4), 2022
BAKCGROUND: Tocilizumab (TCZ) is a new therapeutic alternative for severe cases of COVID-19 pneumonia. AIM: To evaluate the cumulative incidence (CI) of suspected adverse drug reactions (ADR) from TCZ in adult patients with COVID-19. MATERIAL AND METHODS: An active pharmacological surveillance protocol w...

Effect of kefir on increased apoptosis in liver and kidney in cisplatin toxicity

Int. j. morphol; 40 (2), 2022
SUMMARY: Cisplatin is a chemotherapeutic agent inducing liver and kidney damage. In this study, we intended to investigate the impact of kefir beverage, an essential probiotic and functional food, on liver and kidney damage induced by cisplatin. Wistar albino rats were divided into four groups: Control, ...

Parámetros de laboratorio clínico en pacientes con la COVID-19
Clinical laboratory parameters in patients with COVID-19

Rev. cuba. med. mil; 50 (2), 2021
Introducción: Conocer las alteraciones en exámenes de laboratorio clínico, es de utilidad en el diagnóstico y el progreso de pacientes con la COVID-19. Objetivo: Describir los parámetros de laboratorio clínico en pacientes diagnosticados con la COVID-19. Métodos: Estudio descriptivo en 82 pacien...

Silymarin's defensive role against hepatotoxicity induced by amiodarone in albino rats

Int. j. morphol; 39 (2), 2021
SUMMARY: Amiodarone (AMD), an orally powerful antidysrhythmic medication that has caused hepatotoxicity on long-term administration, is commonly used across the world. Silymarin ameliorative effects (SLM); this research elucidated the magnitude of the damage to the liver tissue in AMD. We divided 24 albi...

Análise do fêmur de ratas tratadas com ocitocina e submetidas ao treinamento de força durante a periestropausa

A diminuição nas concentrações de estrógeno, como o que ocorre no período da perimenopausa e menopausa, contribui para o aumento do turnover ósseo, com taxa de reabsorção superior à de formação óssea que favorece a instalação da osteoporose, doença silenciosa que determina fragilidade ós...

The effect of Farnesoid X receptor agonist tropifexor on liver damage in rats with experimental obstructive jaundice

Acta cir. bras; 36 (9), 2021
ABSTRACT Purpose: To investigate experimentally the effects of Tropifexor, a farnesoid X receptor agonist, on liver injury in rats with obstructive jaundice. Methods: Forty healthy Wistar albino female rats were divided randomly in selected groups. These groups were the sham group, control group, vehic...

Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation

Acta cir. bras; 36 (11), 2021
ABSTRACT Purpose: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. Methods: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group. We recorded the weight change of mice in each group...

Assessment of liver disease by non-invasive methods in perinatally infected Brazilian adolescents and young adults living with Human Immunodeficiency Virus (HIV)

Braz. j. infect. dis; 25 (3), 2021
ABSTRACT Introduction: Effective and long-term combined antiretroviral therapy (cART) has decreased morbidity and mortality in HIV-infected individuals. Despite treatment advances, HIV-infected children continue to develop noninfectious conditions, including liver fibrosis. Methods: Cross-sectional stu...

Células madre adiposas humanas disminuyen el daño de la fibrosis hepática con baja persistencia de células trasplantadas en ratas

Int. j. morphol; 38 (5), 2020
RESUMEN: En la enfermedad hepática crónica el trasplante ortotópico es la única alternativa terapéutica actual pero es limitada por falta de donantes. Ensayos con células madre adultas en daño hepático agudo evidencian promisorios resultados. El objetivo de este trabajo fue evaluar en ratas con d...