LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Memory impairments and increased GFAP expression in hippocampal astrocytes following hypercaloric diet in rats

Bondan, Eduardo Fernandes; Cardoso, Carolina Vieira; Martins, Maria de Fátima Monteiro; Otton, Rosemari.

Arq. neuropsiquiatr; 77 (9), 2019

ABSTRACT Objective: Hypothalamic inflammation and glial fibrillary acidic protein (GFAP) overexpression in astrocytes are well described in obese animals, as are some cognitive and memory deficits. As the hippocampus plays important roles in the consolidation of information, this investigation aimed to ...

Tejido Adiposo/metabolismo, Astrocitos/química, Dieta Alta en Grasa/efectos adversos, Proteína Ácida Fibrilar de la Glía/análisis, Proteína Ácida Fibrilar de la Glía/metabolismo, Hipocampo/citología, Inmunohistoquímica, Trastornos de la Memoria/etiología, Trastornos de la Memoria/metabolismo, Obesidad/complicaciones, Obesidad/metabolismo, Ratas Wistar, Valores de Referencia, Factores de Tiempo

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Phytochemical analysis of hydroethanolic extract of Turnera diffusa Willd and evaluation of its effects on astrocyte cell death

ABSTRACT Objective To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae; T. diffusa), as well as its toxicity in astrocytes. Methods Chemical analyses of hydroethanolic extract from powdered aerial parts ofT. diffusa wer...