Abstract Background: Cigarette smoking is usually associated with hypertension and may modify vasoconstrictor response. Objective: The present study aimed to analyze and compare the interaction of passive cigarette smoking and hypertension on epinephrine and felypressin blood pressure effects after int...
Abstract Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion...
Abstract Purpose: To investigate the role of atenolol in the gene expression of caspase 1 (Casp1) and Bcl2L1 on vascular endothelium of rat intestine after ischemia and reperfusion (IR). Methods: Eighteen adult male Wistar rats were randomly divided into 3 groups (n=6): SG (Sham group): no clamping o...
Abstract Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+...
Atualmente muitos fármacos empregados na terapêutica são compostos quirais. O propranolol e o atenolol são ß-bloqueadores empregados no tratamento da hipertensão, angina do peito e outros distúrbios cardiovasculares. Estes fármacos são caracterizados pela presença de pelo menos um carbono quira...
Estudamos o efeito anti-hipertensivo por 6 meses de uma formulaçäo galêmica em uma única cápsula da associaçäo de nifedipina 20 mg e atenolol 50 mg administrada uma vez ao dia a 46 pacientes hipertensos essenciais leves e moderados. quando necessário, a dosagem foi aumentada para 40 mg de nifedip...