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Results: 9

CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis

Zhang, Xiaohao; Lu, Junying; Zhang, Qinghua; Luo, Qiang; Liu, Bin.
Biol. Res; 54 (), 2021
BACKGROUND: Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. However, the underlying mechanism of circRNA in AS has been not understood clearly. ...
Aterosclerosis/genética, MicroARNs/genética, Apoptosis/genética, Histona Desacetilasa 1/genética, Proliferación Celular, Células Endoteliales de la Vena Umbilical Humana, Inflamación/genética, Lipoproteínas LDL, Proteínas Nucleares, ARN Circular, Transactivadores
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The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults

Alves, E S; Henriques, A D; Tonet-Furioso, A C; Paula, R S; Gomes, L O; Moraes, C F; Nóbrega, O T.
Braz. j. med. biol. res; 53 (3), 2020
The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly popul...
Apolipoproteínas B/genética, Aterosclerosis/sangre, Aterosclerosis/genética, Brasil, Enfermedades Cardiovasculares/sangre, Ingestión de Energía, Conducta Alimentaria, Frecuencia de los Genes, Predisposición Genética a la Enfermedad/genética, Genotipo, Lípidos/sangre, Polimorfismo Genético/genética, Factores de Riesgo
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LncRNA HCG11 regulates proliferation and apoptosis of vascular smooth muscle cell through targeting miR-144-3p/FOXF1 axis in atherosclerosis

Liu, Yi; Cui, Xiyun; Wang, Cong; Zhao, Sihai.
Biol. Res; 53 (), 2020
BACKGROUND: Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people's life and health. In recent years, long non-coding RNA (lncRNA) has been found to be involved in gene expression regulation, but...
Factores de Transcripción Forkhead/genética, MicroARNs/genética, Miocitos del Músculo Liso/citología, ARN Largo no Codificante/genética, Aterosclerosis/genética, Apoptosis/genética, Proliferación Celular/genética, Músculo Liso Vascular/citología
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An update on the tools for creating transgenic animal models of human diseases - focus on atherosclerosis

Volobueva, A S; Orekhov, A N; Deykin, A V.
Braz. j. med. biol. res; 52 (5), 2019
Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disea...
Animales Modificados Genéticamente, Aterosclerosis/genética, Aterosclerosis/fisiopatología, Investigación Biomédica/métodos, Modelos Animales de Enfermedad, Técnicas de Transferencia de Gen, Ingeniería Genética/métodos, Nucleasas de los Efectores Tipo Activadores de la Transcripción/metabolismo
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Identificación de familias aterovulnerables en la atención primaria de salud
Determination of atherosclerosis-vulnerable families in the primary health care

Hernández Gárciga, Francisco Felipe.
Rev. cuba. salud pública; 43 (4), 2017
Introducción: La aterosclerosis, es la principal causa de las llamadas Grandes Crisis Ateroscleróticas. Objetivo: Identificar familias aterovulnerables mediante la búsqueda de factores de riesgo y señales tempranas y tardías de aterosclerosis. Método: Se realizó, hace doce años, un estudio descri...
Estudios Transversales, Epidemiología Descriptiva, Aterosclerosis/etiología, Aterosclerosis/genética, Estudios Retrospectivos, Tablas de Vida
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Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients

Wu, Hui; Weng, Yingfeng; Zheng, Lan; Li, Huanyin; Gong, Qi; Fu, Yi; Zhao, Jing.
Arq. neuropsiquiatr; 74 (11), 2016
ABSTRACT The complement system has been confirmed to play an increasingly important role in ischemic stroke (IS). This study aimed to determine whether the single-nucleotide polymorphism of the complement 5 (C5) gene independently influences the occurrence, severity, and long-term outcome of IS in Chines...
Pueblo Asiatico/genética, Aterosclerosis/genética, China, Complemento C5/genética, Estudios de Asociación Genética, Predisposición Genética a la Enfermedad/genética, Polimorfismo de Nucleótido Simple, Índice de Severidad de la Enfermedad, Accidente Cerebrovascular/genética
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Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score

Souza-Nogueira, Andre de; Camargo, Alissana Ester; Remondi, Felipe Assan; Paoliello, Monica Maria Bastos; Richter, Rebecca J; Furlong, Clement E; Barbosa, Decio Sabbatini; Maes, Michael; Moreira, Estefania Gastaldello.
Arch. endocrinol. metab. (Online); 60 (5), 2016
ABSTRACT Objective Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association of PO...
Arildialquilfosfatasa/sangre, Arildialquilfosfatasa/genética, Aterosclerosis/genética, HDL-Colesterol/sangre, LDL-Colesterol/sangre, Estudios Transversales, Interacción Gen-Ambiente, Estudios de Asociación Genética, Genotipo, Hidrólisis, Modelos Logísticos, Polimorfismo Genético, Valores de Referencia, Medición de Riesgo/métodos, Factores de Riesgo, Factores Sexuales, Fumar/efectos adversos, Triglicéridos/sangre
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Doença cardiovascular em pacientes transplantados: associação com fatores da coagulação e seus polimorfismos genéticos

Keitel, Elizete.
As doenças decorrentes da aterosclerose apresentam uma prevalência elevada entre pacientes submetidos a transplante de órgãos sólidos comparativamente à população em geral. Os motivos para esta discrepância podem estar na maior exposição dos pacientes transplantados a fatores de risco cardiova...
Aterosclerosis/etiología, Aterosclerosis/genética, Trasplante de Riñón/efectos adversos, Estudios de Casos y Controles