Results: 7

Are statins a risk factor in patients with atherosclerosis?

Int. j. morphol; 40 (5), 2022
SUMMARY: Statins inhibit cholesterol synthesis, but also have other pleiotropic effects. There are indications that they affect macrophage survival trough the regulation of apoptosis. We analyzed 50 samples of aortic wall, selected based on statins in patients' therapy (n=25, Th-S group) or statin-free t...

Up-regulated miR-106b inhibits ox-LDL-induced endothelial cell apoptosis in atherosclerosis

Braz. j. med. biol. res; 53 (3), 2020
This research aimed to explore the molecular mechanism of microRNA (miR)-106b in cell apoptosis of atherosclerosis (AS). Human aortic endothelial cells (HAECs) were divided into control group, oxidized-low-density lipoproteins (ox-LDL) group, miR-106b NC+ox-LDL group, miR-106b mimics+ox-LDL group, miR-10...

Central role of obesity in endothelial cell dysfunction and cardiovascular risk

SUMMARY Atherosclerosis is the leading cause of mortality in the contemporary world. The critical role of the endothelial cells (EC) in vascular homeostasis, the metabolic changes that take place when the cell is activated, and the elements involved in these processes have been widely explored over the p...

Comportamento de alguns parâmetros bioquímicos relacionados a fatores de risco de doenças cardiovasculares: etilismo e tabagismo

Estudou-se as influências dos fatores de risco, como alcoolismo e tabagismo, sobre as doenças cardiovasculares ateroscleróticas em populaçäo de uma regiäo pertencente à area Metropolitana de Säo Paulo. A avaliaçäo da intensidade desses fatores de risco a que as pessoas de 20 anos e mais residen...