Results: 7

Identification and Characterization of the ATG8, a Marker of Eimeria tenella Autophagy

Abstract Autophagy plays an important role in maintaining cell homeostasis through degradation of denatured proteins and other biological macromolecules. In recent years, many researchers focus on mechanism of autophagy in apicomplexan parasites, but little was known about this process in avian coccidia....

Erratum: Identification and Characterization of the ATG8, a Marker of Eimeria tenella Autophagy

Anon.

LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis

Biol. Res; 53 (), 2020
BACKGROUND: Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenes...

Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells

Braz. j. med. biol. res; 52 (11), 2019
Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment. The potential mechanisms of cancer cell resistance to Taxol are not completely clear. It has been reported that micro...

Long non-coding RNA MALAT1 enhances the apoptosis of cardiomyocytes through autophagy inhibition by regulating TSC2-mTOR signaling

Biol. Res; 52 (), 2019
BACKGROUND: Our previous study showed that knockdown of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) attenuated myocardial apoptosis in mouse acute myocardial infarction (AMI). This study aims to explore whether MALAT1 enhanced cardiomyocyte apoptosis via au...

Genes related to maintenance of autophagy and successful aging

Arq. neuropsiquiatr; 76 (12), 2018
ABSTRACT Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carrie...

Mecanismos moleculares envolvidos em citoproteção e transformação maligna de células-beta pancreáticas

O transplante de ilhotas pancreáticas constitui uma alternativa atraente para o tratamento de diabetes tipo 1 (DM1), contudo, é limitado devido à escassez de doadores de órgãos. O papel da prolactina humana recombinante (rhPRL), que apresenta efeitos benéficos em células-beta, e seu mecanismo de a...