Introducción. El fluconazol es el antifúngico más utilizado para la prevención y el tratamiento de infecciones causadas por el género Cryptococcus, agente etiológico de la criptococosis. La resistencia al fluconazol en los aislamientos de Cryptoccocus neoformans puede hacer fracasar el tratamiento ...
The first report about antimicrobial resistance was published in the 1940s. And today, the antimicrobial resistance has become a worldwide problem. Because of this problem, there is a need to develop new drugs. That’s why we synthesized some novel thiazolidine-4-one derivatives and evaluated their anti...
Resumen Los azoles son fármacos que inhiben la enzima 14α-esteroldemetilasa, impidiendo la unión de ergosterol; esto altera la estructura y función de la pared celular fúngica. Especialmente el grupo de los triazoles: fluconazol, itraconazol, voriconazol, posaconazol e isavuconazol, son una alte...
Satureja khuzistanica Jamzad is known as antiseptic and analgesic agent in folk medicine. The aim of this investigation was to evaluate the anti-candidal activity of S. khuzistanica aerial parts essential oil against clinical isolates of Candida albicans, which were isolated from women with chronic recur...
Resumen La paracoccidioidomicosis es una enfermedad crónica, sistémica y progresiva, sólo descrita en América Latina. Su presentación clínica crónica multifocal es la más prevalente, afectando mayormente a hombres adultos y comprometiendo principalmente a pulmones, sin embargo, puede diseminarse ...
BACKGROUND Candida glabrata ranks second in epidemiological surveillance studies, and is considered one of the main human yeast pathogens. Treatment of Candida infections represents a contemporary public health problem due to the limited availability of an antifungal arsenal, toxicity effects and increas...
Background: Latent tuberculosis has been associated with the persistence of dormant Mycobacterium tuberculosis in the organism of infected individuals, who are reservoirs of the bacilli and the source for spreading the disease in the community. New active anti-TB drugs exerting their metabolic action at ...
Abstract The current increment of invasive fungal infections and the availability of new broad-spectrum antifungal agents has increased the use of these agents by non-expert practitioners, without an impact on mortality. To improve efficacy while minimizing prescription errors and to reduce the high mone...
Antifúngicos/farmacocinética,
Antifúngicos/uso terapéutico,
Área Bajo la Curva,
Aspergilosis/tratamiento farmacológico,
Aspergilosis/metabolismo,
Azoles/farmacocinética,
Azoles/uso terapéutico,
Candidiasis/tratamiento farmacológico,
Candidiasis/metabolismo,
Relación Dosis-Respuesta a Droga,
Equinocandinas/farmacocinética,
Equinocandinas/uso terapéutico,
América Latina,
Pruebas de Sensibilidad Microbiana,
Polienos/farmacocinética,
Polienos/uso terapéutico,
Triazoles/farmacocinética,
Triazoles/uso terapéutico
Abstract Objective Candida albicans is the primary causative agent of oral candidosis, and one of its key virulent attributes is considered to be its ability to produce extracellular phospholipases that facilitate cellular invasion. Oral candidosis can be treated with polyenes, and azoles, and the more ...
Antifúngicos/farmacología,
Candida albicans/efectos de los fármacos,
Candida albicans/metabolismo,
Candidiasis Bucal/microbiología,
Fosfolipasas/biosíntesis,
Antifúngicos/uso terapéutico,
Azoles/farmacología,
Azoles/uso terapéutico,
Candida albicans/patogenicidad,
Candidiasis Bucal/tratamiento farmacológico,
Dentaduras,
Diabetes Mellitus,
Equinocandinas/farmacología,
Activación Enzimática,
Espacio Extracelular,
Pruebas de Sensibilidad Microbiana,
Polienos/farmacología,
Polienos/uso terapéutico,
Fumar,
Factores de Virulencia,
Candida albicans/aislamiento & purificación
SUMMARYConsidered to be an emerging endemic mycosis in Latin America, paracoccidioidomycosis is characterized by a chronic course and involvement of multiple organs in immunocompromised hosts. Infection sequelae are mainly related to pulmonary and adrenal insufficiency. The host-parasite interaction resu...
