La biología molecular tiene mayor afinidad en las áreas de la salud,
en odontología su principal aplicación ha sido en la identificación de
microorganismos orales patógenos mediante el uso de secuencias genéticas
específicas (ácido desoxirribonucleico [DNA], ácido ribonucleico
[RNA] y proteína...
As síndromes autoinflamatórias são doenças raras, genéticas de envolvimento prioritário da imunidade inata. Avanços nas técnicas de sequenciamento genético permitiram dissecar os genes envolvidos nestas doenças, continuamente organizando o quebra-cabeça genético e fisiopatológico de tais des...
Introdução: Pythium insidiosum é um microrganismo fenotipicamente semelhante aos fungos com hifas, mas este oomyceto pertencente ao filo Straminofila, filogeneticamente separado dos fungos verdadeiros. Usando metodologias moleculares, isolados de P. insidiosum foram colocados em três grupos filogené...
Lerario, Antonio Marcondes;
Mohan, Dipika R;
Montenegro, Luciana Ribeiro;
Funari, Mariana Ferreira de Assis;
Nishi, Mirian Yumie;
Narcizo, Amanda de Moraes;
Benedetti, Anna Flavia Figueredo;
Oba-Shinjo, Sueli Mieko;
Vitorino, Aurélio José;
Santos, Rogério Alexandre Scripnic Xavier dos;
Jorge, Alexander Augusto de Lima;
Onuchic, Luiz Fernando;
Marie, Suely Kazue Nagahashi;
Mendonca, Berenice Bilharinho.
OBJECTIVES: High-throughput sequencing of genomes, exomes, and disease-focused gene panels is becoming increasingly common for molecular diagnostics. However, identifying a single clinically relevant pathogenic variant among thousands of genetic polymorphisms is a challenging task. Publicly available gen...
Aortic dissection is characterized by the redirection of blood flow, which flows through an intimal tear into the aortic media. The purpose of this study was to find potential acute type A aortic dissection (AAAD)-related genes and molecular mechanisms by bioinformatics. The gene expression profiles of G...
Given that the pathogenesis of ankylosing spondylitis (AS) remains unclear, the aim of this study was to detect the potentially functional pathway cross-talk in AS to further reveal the pathogenesis of this disease. Using microarray profile of AS and biological pathways as study objects, Monte Carlo cros...
Área Bajo la Curva,
Bases de Datos Genéticas,
Perfilación de la Expresión Génica/métodos,
Expresión Génica,
Estudios de Asociación Genética,
Análisis por Micromatrices/métodos,
Método de Montecarlo,
Receptor Cross-Talk/fisiología,
Valores de Referencia,
Transducción de Señal/genética,
Espondilitis Anquilosante/genética
Abstract Introduction: Nasopharyngeal carcinoma is the most common cancer originating from the nasopharynx. Objective: To study the mechanisms of nasopharyngeal carcinoma, we analyzed GSE12452 microarray data. Methods: GSE12452 was downloaded from the Gene Expression Omnibus database and included 31 n...
Análisis de Varianza,
Carcinoma/genética,
Carcinoma/patología,
Quimiocina CXCL10/genética,
Quimiocina CXCL9/genética,
Análisis por Conglomerados,
Bases de Datos Genéticas,
Regulación hacia Abajo,
Perfilación de la Expresión Génica,
Expresión Génica,
Redes Reguladoras de Genes,
Análisis por Micromatrices,
Carcinoma Nasofaríngeo,
Neoplasias Nasofaríngeas/genética,
Neoplasias Nasofaríngeas/patología,
Proteínas Nucleares/genética,
Factores de Transcripción/genética,
Regulación hacia Arriba
OBJECTIVES: Clinically, patients with chronic heart failure arising from different etiologies receive the same treatment. However, the prognoses of these patients differ. The purpose of this study was to elucidate whether the pathogenesis of heart failure arising from different etiologies differs. METHO...
Cardiomiopatías/complicaciones,
Cardiomiopatías/genética,
Estudios de Casos y Controles,
Bases de Datos Genéticas,
Expresión Génica,
Perfilación de la Expresión Génica,
Regulación de la Expresión Génica,
Insuficiencia Cardíaca/genética,
Insuficiencia Cardíaca/terapia,
Análisis por Micromatrices,
Mapas de Interacción de Proteínas,
Valores de Referencia
Background: Idesia polycarpa Maxim. var. vestita Diels, a dioecious plant, is widely used for biodiesel due to the high oil content of its fruits. However, it is hard to distinguish its sex in the seedling stage, which makes breeding and production problematic as only the female tree can produce fruits, ...
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the year...
Trastornos Respiratorios/genética,
Sepsis/complicaciones,
Sepsis/genética,
Estudios de Asociación Genética,
Transcriptoma,
Ciclo Celular/genética,
Bases de Datos Genéticas,
Regulación hacia Abajo,
Perfilación de la Expresión Génica,
Marcación de Gen,
Mapas de Interacción de Proteínas,
Factores de Transcripción,
Regulación hacia Arriba
