SUMMARY: Marein is a flavonoid compound that reduces blood glucose and lipids and has a protective effect in diabetes. However, the effect and mechanism(s) of marein on renal endothelial-mesenchymal transition in diabetic kidney disease (DKD) have not been elucidated. In this study, single-cell sequencin...
INTRODUCTION: Breast cancer is one of the main causes of death in women. Luminal tumors A and B show good response with hormonal treatments, tumors that overexpress HER-2 can be treated with monoclonal antibodies, whereas triple negative tumors have few treatments available because they present low or ab...
SUMMARY: Calcium-activated chloride channel regulator 1 (CLCA1) is associated with cancer progression. The expression and immunologic function of CLCA1 in stomach adenocarcinoma (STAD) remain unclear. In this investigation, the expression of CLCA1 in STAD tissues and its involvement in the progression an...
Neoplasias Gástricas/metabolismo,
Adenocarcinoma/metabolismo,
Canales de Cloruro/metabolismo,
Inmunohistoquímica,
Pronóstico,
Canales de Cloruro/genética,
Mutación,
Análisis de Supervivencia,
Neoplasias Gástricas/inmunología,
Adenocarcinoma/inmunología,
Canales de Cloruro/inmunología,
Biomarcadores de Tumor,
Biología Computacional
SUMMARY: Colon adenocarcinoma (COAD) is a prevalent disease worldwide, known for its high mortality and morbidity rates. Despite this, the extent of investigation concerning the correlation between COAD's CLCA1 expression and immune cell infiltration remains insufficient. This study seeks to examine the ...
Canales de Cloruro/metabolismo,
Neoplasias del Colon/inmunología,
Adenocarcinoma/inmunología,
Biología Computacional,
Pronóstico,
Análisis de Supervivencia,
Análisis de Regresión,
Análisis Multivariante,
Inmunohistoquímica,
Canales de Cloruro/inmunología,
Neoplasias del Colon/metabolismo,
Adenocarcinoma/metabolismo
SUMMARY: We investigated the expression and clinical significance of miR-15b-5p in clear cell renal cell carcinoma (RCC) through bioinformatics analysis and experimental verification. The differentially expressed miRNAs were screened in the GEO database. Venn diagram showed that there were 5 up-regulated...
Neoplasias Renales/patología,
Neoplasias Renales/genética,
Carcinoma de Células Renales/patología,
Carcinoma de Células Renales/genética,
MicroARNs,
Metástasis de la Neoplasia,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Invasividad Neoplásica,
Biología Computacional,
Análisis de Supervivencia,
Movimiento Celular
INTRODUCTION: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed. Therefore, the search for biomarkers contributes to the improvement and development of therapies. OBJ...
Abstract Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its i...
ABSTRACT Introduction The recent development of the deep learning algorithm as a new multilayer network machine learning algorithm has reduced the problem of traditional training algorithms easily falling into minimal places, becoming a recent direction in the learning field. Objective Design and valid...
As leishmanioses são doenças tropicais negligenciadas com alta endemicidade e que afetam milhares de pessoas no mundo. Sua infecção é causada por parasitos protozoários do gênero Leishmania. A diversidade biológica entre as espécies é quem permite determinar as manifestações clínicas, sendo ...
ABSTRACT Clinical diagnosis of several neurodegenerative disorders based on clinical phenotype is challenging due to its heterogeneous nature and overlapping disease manifestations. Therefore, the identification of underlying genetic mechanisms is of paramount importance for better diagnosis and therapeu...
