Dentre os subtipos de câncer de mama, o triplo negativo (TNBC) é o que apresenta as maiores taxas de mortalidade, sendo, portanto, considerado um enorme desafio para a clínica. O uso de moléculas como marcadores tumorais vem auxiliando o clínico no diagnóstico, no prognóstico e, até mesmo, no tra...
Alsagaby, Suliman A;
Brewis, Ian A;
Vijayakumar, Rajendran;
Alhumaydhi, Fahad A;
Alwashmi, Ameen S;
Alharbi, Naif K;
Al Abdulmonem, Waleed;
Premanathan, Mariappan;
Pratti, Guy;
Fegan, Christopher;
Pepper, Christopher;
Brennan, Paul.
BACKGROUND: Chronic lymphocytic leukaemia (CLL) is a neoplasm of B-cells characterized by variable prognosis. Exploring the proteome of CLL cells may provide insights into the disease. Therefore, eleven proteomics experiments were conducted on eleven primary CLL samples. RESULTS: We reported a CLL proteo...
The current study found that high Zeste White 10 interactor (ZWINT) expression is related to the poor prognosis of patients with a variety of cancers. This study mainly explored the relationship between the expression level of ZWINT and the prognosis of patients with lung adenocarcinoma (LUAD). Briefly, ...
El cáncer gástrico (CG) es la neoplasia del tubo digestivo más prevalente en el mundo, asociada a factores genéticos del hospedero y externos, como infección por Helicobacter pylori. La patogénesis incluye inflamación crónica mediada por citocinas del microambiente tumoral, detectables sistémica...
Células TH1,
Neoplasias Gástricas/complicaciones,
Plasma/química,
Tracto Gastrointestinal/patología,
Adenocarcinoma/complicaciones,
Citocinas/análisis,
Infecciones por Helicobacter/complicaciones,
Inmunoglobulina G/análisis,
Interleucina-1/análisis,
Interleucina-10/análisis,
Interleucina-6/análisis,
Microambiente Tumoral,
Células Th2,
Células Th17,
Neoplasias/complicaciones,
Biomarcadores de Tumor/análisis
Rodríguez, Héctor;
Cortés-Chau, Felipe;
Cortés-Pino, Felipe;
Aguirre, Pablo;
Bravo, Gonzalo;
Gallegos, Iván;
Arriaza, Camilo;
Cuéllar, Caroll;
Aguayo, Francisco;
Espinoza-Navarro, Omar.
The different pathologies of the prostate, involve the presence of a new microenvironment where inflammatory cells are actively recruited. This research explores the presence of mast cells and eosinophils associated with age and the evaluation of prostate cancer progress (Gleason Index). Forty two biopsi...
Neoplasias de la Próstata/patología,
Próstata/patología,
Detección Precoz del Cáncer,
Neoplasias de la Próstata/diagnóstico,
Biopsia,
Chile,
Biomarcadores de Tumor/análisis,
Clasificación del Tumor,
Factores de Edad,
Eosinofilia/patología,
Mastocitosis/patología
Introducción: Los biomarcadores son claves en el diagnóstico y pronóstico del lupus eritematoso sistémico en el cual las manifestaciones clínicas son extremadamente complejas y heterogéneas. Objetivo: Determinar el valor clínico de los inmunocomplejos circulantes en pacientes con lupus eritemat...
Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as ...
Análisis de Varianza,
Biomarcadores de Tumor/análisis,
Estudios de Casos y Controles,
Leucoplasia Bucal/patología,
Liquen Plano Oral/patología,
Modelos Lineales,
MicroARNs/análisis,
Neoplasias de la Boca/química,
Neoplasias de la Boca/patología,
Fibrosis de la Submucosa Bucal/patología,
Lesiones Precancerosas/patología,
Curva ROC,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Saliva/química,
Índice de Severidad de la Enfermedad
Abstract The purpose of this study was to analyze the differential expression of DEC1 in oral normal mucosa (NM), oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Surgically excised specimens from patients with OLK (n = 47), OSCC (n = 30) and oral normal mucosa (n=11) were immunostained fo...
Factores de Edad,
Análisis de Varianza,
Biomarcadores de Tumor/análisis,
Carcinoma de Células Escamosas/patología,
Transformación Celular Neoplásica/patología,
Inmunohistoquímica,
Leucoplasia Bucal/patología,
Persona de Mediana Edad,
Neoplasias de la Boca/patología,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Riesgo,
Estadísticas no Paramétricas,
Proteínas Supresoras de Tumor/análisis
Czeczko, Leticia Elizabeth Augustin;
Ribas, Carmen Australia Paredes Marcondes;
Czeczko, Nicolau Gregori;
Skare, Thelma Larocca;
Yamakawa, Camila Kienen;
Gionedis, Guilherme;
Vasconcelos, Cecilia;
Bremer, Fabiola Pabst;
Castoldi, Diogo Francesco;
Gasser, Martin;
Waaga-Gasser, Ana Maria.
ABSTRACT Background: CD133 and AXL have been described as cancer stem cell markers, and c-MYC as a key regulatory cellular mechanism in colorectal cancer (CRC). Aim: Evaluate the prognostic role of the biomarkers CD133, AXL and c-MYC and their association with clinicopathologic characteristics in colo...
SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms' tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. ...
