LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma

Miric, Mirjana; Ristic, Sinisa; Joksimovic, Bojan N; Medenica, Snezana; Racic, Maja; Ristic, Slavica; Joksimovic, Vedrana R; Skipina, Mirjana.

Rev. méd. Chile; 144 (4), 2016

Background: Benzodiazepines have a direct bronchodilatory effect. Methacholine is a non-selective muscarinic receptor agonist causing bronchoconstriction. Aim: To examine the effects of inhaled benzodiazepines, modulating bronchoconstriction induced by methacholine in patients with asthma. Patients and M...

Asma/prevención & control, Broncoconstricción/efectos de los fármacos, Broncoconstrictores/antagonistas & inhibidores, Diazepam/farmacología, Cloruro de Metacolina/antagonistas & inhibidores, Receptores de GABA/uso terapéutico, Administración por Inhalación, Antropometría, Asma/fisiopatología, Benzodiazepinas/uso terapéutico, Pruebas de Provocación Bronquial/métodos, Relación Dosis-Respuesta a Droga, Volumen Espiratorio Forzado/efectos de los fármacos, Volumen Espiratorio Forzado/fisiología, Valores de Referencia, Reproducibilidad de los Resultados, Factores de Tiempo, Capacidad Vital/fisiología

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Protective effects of different doses of inhaled fenoterol on methacholine-induced bronchoconstriction in asthmatic children

Objective: To evaluate the protective effect of different doses of inhaled fenoterol (F) on bronchoconstriction induced by methacholine (M). Design: randomized double-blind study. Setting: Referrence center. Participants: 9 children (aged from 7 to 15 years old), with mild or moderate asthma and allergic...