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Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice: the development of a pharmacological approach for rabies treatment

Vigerelli, Hugo; Sciani, Juliana M; Pereira, Patricia M. C; Lavezo, Aline A; Silva, Andrea C. R; Collaço, Rita C. O; Rocha, Thalita; Bueno, Thais C; Pimenta, Daniel C.
J. venom. anim. toxins incl. trop. dis; 26 (), 2020
Between 40,000-70,000 people die yearly of rabies, an incurable disease. Besides post-bite vaccination, no treatment is available for it. Methods: First, virus dilution for antiviral effects in mice was determined. Then, animals were treated as follows: control (NaCl 250 µL/animal/day); bufotenine (0.6...
Ratones/virología, Bufotenina, Alcaloides, Triptófano, Rabia, Preparaciones Farmacéuticas
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Synergic effects between ocellatin-F1 and bufotenine on the inhibition of BHK-21 cellular infection by the rabies virus

Cunha Neto, Rene dos Santos; Vigerelli, Hugo; Jared, Carlos; Antoniazzi, Marta Maria; Chaves, Luciana Botelho; Silva, Andréa de Cássia Rodrigues da; Melo, Robson Lopes de; Sciani, Juliana Mozer; Pimenta, Daniel C.
J. venom. anim. toxins incl. trop. dis; 21 (), 2015
Background Rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. Animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, incl...
Virus de la Rabia, Bufotenina, Secreciones Corporales, Péptidos
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Bufotenine is able to block rabies virus infection in BHK-21 cells

Vigerelli, Hugo; Sciani, Juliana Mozer; Jared, Carlos; Antoniazzi, Marta Maria; Caporale, Graciane Maria Medeiros; Silva, Andréa de Cássia Rodrigues da; Pimenta, Daniel C.
J. venom. anim. toxins incl. trop. dis; 20 (), 2014
Background Rabies is a fatal zoonotic neglected disease that occurs in more than 150 countries, and kills more than 55.000 people every year. It is caused by an enveloped single stranded RNA virus that affects the central nervous system, through an infection initiated by the muscular nicotinic acetylchol...
Bufotenina, Virus de la Rabia, Infecciones, Espectrometría de Masas, Productos Biológicos
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