Abstract Glioblastoma multiforme is a tumor of the central nervous system. Focal Adhesion Kinase (FAK) and αB-crystalline are two proteins involved in glioblastoma development. In this study, we investigated whether the FAK/αB-crystalline interaction is important for glioblastoma cells, we aimed to inv...
A quimioinformática, definida como o emprego de técnicas informáticas na solução de problemas da química, evolui em conjunto com o desenvolvimento de ferramentas computacionais e é de grande relevância para o planejamento racional de fármacos ao otimizar etapas do desenvolvimento de novas moléc...
Aminoácidos/agonistas,
Asparagina/análogos & derivados,
d0487880,
Células/clasificación,
ADN/efectos adversos,
d0151950,
d0199840,
d0080240,
Neoplasias/patología,
ddcs0518460,
Preparaciones Farmacéuticas/análisis,
Quimioinformática/instrumentación
A via Hippo consiste em uma cascata de serina-treonina quinases que desempenha um papel central na transdução de sinais mecânicos. Em mamíferos, o eixo canônico da via consiste na ativação das quinases MST1 e MST2 (codificadas pelos genes STK4 e STK3, respectivamente) e LATS1 e LATS2. A ativação...
Abstract Lung cancer is a major cause of cancer-related death worldwide. This study investigated the regulatory effects of the microRNA-99a-5p (miR-99a-5)/VLDLR axis on lung cancer cell sensitivity to chemotherapy and its mechanism. miR-99a-5p and VLDLR expression levels were quantified using RT-qPCR and...
Abstract The purpose of the current work was to assess a possible role of cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) in the metabolic activation of 2,6-dimethylaniline (2,6-DMA) and also clarify the function of DNA repair in affecting the ultimate mutagenic potency. Two cell lines, nu...
Responsável por milhões de óbitos anuais e um grande custo para a saúde pública, o câncer é a segunda maior causa de mortes no mundo. Dentre seus diversos tipos, o câncer de pulmão, além da alta incidência, é um dos mais letais. A exposição a substâncias tóxicas provenientes da combustão...
Proteómica/clasificación,
Neoplasias Pulmonares/patología,
Productos de Tabaco/clasificación,
Carcinogénesis,
Análisis de Varianza,
Células/clasificación,
Estrés Oxidativo,
Interpretación Estadística de Datos,
Muerte Celular,
Neoplasias,
Niacinamida/agonistas
Abstract The consumption of cosmetics has been increasing every year and is expected to reach $675 billion by 2020 at an estimated growth rate of 6.4% per year. Exposure to skin irritants is the major cause of non-immunological inflammation of the skin. Therefore, the safety evaluation of cosmetic preser...
Borges, Gabriel Silva Marques;
Prazeres, Pedro Henrique Dias Moura;
Souza, Ângelo Malachias de;
Yoshida, Maria Irene;
Vilela, José Mario Carneiro;
Silva, Aline Teixeira Maciel e;
Oliveira, Mariana Silva;
Gomes, Dawidson Assis;
Andrade, Margareth Spangler;
Souza-Fagundes, Elaine Maria de;
Ferreira, Lucas Antônio Miranda.
Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) ...
Lignosus rhinocerotis (tiger milk mushroom) is widely used by the indigenous people of Malaysia as a traditional remedy. The present study was carried out in order to evaluate the antioxidant, cytotoxic and anti-neuroinflammatory activities of L. rhinocerotis extract on brain microglial cells (BV2). The ...
The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn't show statistically significant neurotoxic ...
Amidas/agonistas,
Cafeína/antagonistas & inhibidores,
Células/clasificación,
Economía,
Encéfalo/patología,
Fármacos Neuroprotectores/análisis,
Glutatión/farmacología,
Neuroprotección,
Oxidopamina,
Supervivencia Celular,
Sinaptosomas
