Abstract The present study investigated the effects of valerian methanolic extract and valerenic acid on the expression of LL-37 gene and protein in A549 and MRC5 line cells. After preparing Valerian seeds, sowing them in March 2020, and harvesting the rhizome in October 2020, the extract was prepared fr...
Valeriana/efectos adversos,
Extractos Vegetales/efectos adversos,
Catelicidinas/efectos adversos,
Genes/genética,
Cromatografía Líquida de Alta Presión/métodos,
ddcs0244440,
Células A549/clasificación,
Hígado/anomalías,
Péptidos Catiónicos Antimicrobianos/agonistas,
d0024700,
Western Blotting/instrumentación
Abstract In the recent past, drug delivery through nanoparticles is considered an effective tool to treat various diseases. Biopolymeric nanoparticles such as protein based nanoparticles have vital role as drug carrier as it is non-antigenic, and easily biodegradable. Curcumin, plant polyphenolic antican...
Técnicas In Vitro,
Nanopartículas,
Caseínas,
Curcumina,
Apoptosis,
Concentración 50 Inhibidora,
Células A549,
Liberación de Fármacos,
Antineoplásicos/farmacología,
Curcumina/farmacocinética,
Antineoplásicos/farmacocinética
Abstract Increasing biological activity and phytochemical investigations on Eryngium species showed its potential as pharmaceutical approach. Eryngium kotschyi Boiss. is one of the species of Eryngium genus and is endemic to Turkey. It is known that this plant is traditionally used in the South-western ...
Abstract The main aim of the study is to quantify the cytotoxic property of the Fucoidan extracted from the Turbinaria conoides using the MTT assay with the standard fucose. Fucoidan was extracted using the soaked water method and it was determined using the HPLC procedure the obtained Test sample Fucoid...
Técnicas In Vitro/instrumentación,
Células MCF-7,
Células A549,
Citotoxinas/efectos adversos,
Cromatografía Líquida de Alta Presión/métodos,
Concentración 50 Inhibidora,
Fibroblastos/clasificación,
Fucosa/análogos & derivados,
Línea Celular,
Neoplasias Pulmonares/patología,
Neoplasias de la Mama/patología
BACKGROUND: Leaves of the natural plant lotus are used in traditional Chinese medicine and tea production. They are rich in flavonoids. METHODS: In this study, lotus leaf flavonoids (LLF) were applied to human lung cancer A549 cells and human small cell lung cancer cells H446 in vitro to verify the effec...
Apoptosis/efectos de los fármacos,
Flavonoides/farmacología,
Lotus/química,
Neoplasias Pulmonares/patología,
Especies Reactivas de Oxígeno/metabolismo,
Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo,
Células A549,
Proliferación Celular,
Neoplasias Pulmonares/tratamiento farmacológico,
Fitoquímicos/farmacología,
Hojas de la Planta/química,
Transducción de Señal/efectos de los fármacos
Abstract Chronic inflammation is a common indication of several diseases, e.g. asthma, chronic obstructive pulmonary disease (COPD), atherosclerosis, etc. Benzimidazole derivatives are preferable compounds to design new analgesic and anti-inflammatory substances due to their unique biological features. W...
BACKGROUND: Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluate the therapeutic potential of flavonoid compound vitexin in human NSCLC cells and t...
Antineoplásicos/farmacología,
Apigenina/farmacología,
Apoptosis/efectos de los fármacos,
Carcinoma de Pulmón de Células no Pequeñas/patología,
Neoplasias Pulmonares/patología,
Fosfatidilinositol 3-Quinasas/efectos de los fármacos,
Proteínas Proto-Oncogénicas c-akt/efectos de los fármacos,
Serina-Treonina Quinasas TOR/efectos de los fármacos,
Carcinoma de Pulmón de Células no Pequeñas/metabolismo,
Proliferación Celular/efectos de los fármacos,
Neoplasias Pulmonares/metabolismo,
Potencial de la Membrana Mitocondrial/efectos de los fármacos,
Mitocondrias/efectos de los fármacos,
Transducción de Señal/efectos de los fármacos,
Células A549,
Línea Celular Tumoral,
Ratones Desnudos
Background:
Pore-forming proteins (PFP) are a class of toxins abundant in the venom of sea anemones. Owing to their ability to recognize and permeabilize cell membranes, pore-forming proteins have medical potential in cancer therapy or as biosensors. In the present study, we showed the partial purificat...
Hesperidin, a natural compound, suppresses the epithelial-to-mesenchymal transition through the TGF-β1/Smad signaling pathway. However, studies on the detailed effects and mechanisms of hesperidin are rare. The present study showed that, for A549 alveolar epithelial cells, the anti-proliferative effects...
Alveolar epithelia play an essential role in maintaining the integrity and homeostasis of lungs, in which alveolar epithelial type II cells (AECII) are a cell type with stem cell potential for epithelial injury repair and regeneration. However, mechanisms behind the physiological and pathological roles o...
Células A549/fisiología,
Células Epiteliales Alveolares/fisiología,
Análisis de Varianza,
Acuaporina 5/análisis,
Recuento de Células,
Técnicas de Cultivo de Célula/métodos,
Medios de Cultivo Condicionados,
Immunoblotting,
Microscopía Electrónica de Rastreo,
Mucina 5B/análisis,
Proteína C Asociada a Surfactante Pulmonar/análisis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factor Nuclear Tiroideo 1/análisis,
Factores de Tiempo,
Proteína de la Zonula Occludens-1/análisis
