LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Protective effect of N-acetylcysteine against cisplatin ototoxicity in rats: a study with hearing tests and scanning electron microscopy

Somdaş, Mehmet Akif; Güntürk, İnayet; Balcıoğlu, Esra; Avcı, Deniz; Yazıcı, Cevat; Özdamar, Saim.

Braz. j. otorhinolaryngol. (Impr.); 86 (1), 2020

Abstract Introduction Ototoxicity is a health problem appearing after powerful treatments in serious health conditions. It is sometimes inevitable when treatment of the serious disease is required. Cisplatin is an antineoplastic agent which was investigated previously to reveal increased nitrogen and re...

Acetilcisteína/administración & dosificación, Acetilcisteína/farmacología, Antineoplásicos/efectos adversos, Antioxidantes/administración & dosificación, Antioxidantes/farmacología, Apoptosis, Cisplatino/efectos adversos, Cóclea/patología, Modelos Animales de Enfermedad, Potenciales Evocados Auditivos del Tronco Encefálico, Células Ciliadas Auditivas Externas/efectos de los fármacos, Células Ciliadas Auditivas Externas/patología, Pruebas Auditivas, Microscopía Electrónica de Rastreo, Ototoxicidad/etiología, Ototoxicidad/prevención & control, Sustancias Protectoras/administración & dosificación, Sustancias Protectoras/farmacología, Ratas Wistar, Estereocilios/efectos de los fármacos, Estereocilios/patología

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Ototoxicity of boric acid powder in a rat animal model

Abstract Introduction: Boric acid, which has antiseptic and acidic properties, is used to treat external and middle ear infections. However, we have not found any literature about the effect of boric acid powder on middle ear mucosa and inner ear. Objective: The purpose of this study is to investigate ...