La enfermedad periodontal es una de las principales causas de pérdida dentaria. Clínicamente, esta patología, mediada por la desregulación del sistema inmune producto de una disbiosis ocurrida en el surco gingival, inicia con la inflamación de la encía y evoluciona con el daño irreversible de los ...
Resorción Ósea/microbiología,
Enfermedades Periodontales/microbiología,
Bacterias Anaerobias/fisiología,
Ligando RANK/metabolismo,
Línea Celular Tumoral,
Porphyromonas gingivalis/fisiología,
Prevotella intermedia/fisiología,
Células Cultivadas,
Electroforesis,
Western Blotting,
Ligando RANK/análisis
SUMMARY: We aimed to investigate the protective effect of linoleic acid on liver toxicity induced by methotrexate. The study was carried out in partnership with the Department of Anatomy and Department of Medical Pharmacology of Çukurova University Faculty of Medicine, using the laboratory facilities of...
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Ácido Linoleico/administración & dosificación,
Metotrexato/toxicidad,
Hepatocitos/efectos de los fármacos,
Sustancias Protectoras,
Hígado/efectos de los fármacos,
Ensayo de Inmunoadsorción Enzimática,
Células Cultivadas,
Hígado/citología,
Factor Inductor de la Apoptosis,
Chaperón BiP del Retículo Endoplásmico,
Caspasa 3,
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Antimetabolitos Antineoplásicos/toxicidad
Li, Ni;
Dai, Xiaofeng;
Yang, Fei;
Sun, Yang;
Wu, Xingwen;
Zhou, Qianrong;
Chen, Kai;
Sun, Jian;
Bi, Wei;
Shi, Le;
Yu, Youcheng.
BACKGROUND: Spontaneous spheroid culture is a novel three-dimensional (3D) culture strategy for the rapid and efficient selection of progenitor cells. The objectives of this study are to investigate the pluripotency and differentiation capability of spontaneous spheroids from alveolar bone-derived mesenc...
Cisplatin, the first platinum compound approved for cancer treatment, is widely used in the treatment of various cancers including hepatocellular carcinoma (HCC). HCC incidence rates rise globally. Epithelial mesenchymal transition (EMT) is implicated in cancer invasion and metastasis, which are associat...
Cisplatino/administración & dosificación,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Microscopía Confocal,
Células Cultivadas,
Antineoplásicos/administración & dosificación,
Cadherinas/efectos de los fármacos,
Cadherinas/genética,
Vimentina/efectos de los fármacos,
Vimentina/genética,
Factores de Transcripción de la Familia Snail/efectos de los fármacos,
Factores de Transcripción de la Familia Snail/genética,
Técnica del Anticuerpo Fluorescente,
Cadherinas/metabolismo,
Vimentina/metabolismo,
Factores de Transcripción de la Familia Snail/metabolismo,
Células Hep G2,
Invasividad Neoplásica,
Transición Epitelial-Mesenquimal
Koh, Benson;
Rahman, Farynna Hana Ab;
Matlan, Najwa Amira;
Rajan, Manissha;
Mustaain, Aimi Yasmin;
Lee, Mohamad Ridhwan Mohd Jeffry;
Ramli, Roszalina;
Yunus, Siti Salmiah Mohd;
Idrus, Ruszymah Binti Hj;
Yazid, Muhammad Dain.
BACKGROUND: Functional bioengineered tooth regeneration using autologous or allogeneic alternative differentiated cells sources are thought to have a great potential in replacing conventional dentures. This study investigated the potential of dental pulp stem cells (DPSCs) conditioned medium for odontobl...
Resumo Fundamento As células progenitoras endoteliais (CPEs) desempenham um papel importante na manutenção da função endotelial. A síndrome metabólica (SM) está associada à disfunção das CPEs. Embora o exercício físico tenha um impacto benéfico na atividade das CPEs, seu mecanismo ainda n...
Background/aim: Autophagic cell death and apoptosis of tumor cells has become one of the main objectives in cancer treatment, whereas tumor cell lines are mainly used in studies for providing important data for the evaluation of potential anti cancer substances. In this study, our objecti...
BACKGROUND: In order to produce an effective callus in Echinacea purpurea L.; determination of the explant type and growth regulators that best respond to callus induction and the optimization of the culture conditions to increase the amount of caffeic acid derivatives (CADs) in the obtained callus. CADs...
SUMMARY OBJECTIVE: In this study, we aimed at investigating the role of isoleucyl-tRNA synthetase in the growth, migration, and angiogenesis of human umbilical vein endothelial cells and the underlying molecular mechanism. METHODS: To assess the role of isoleucyl-tRNA synthetase, we silenced isoleucyl-...
The aim of this study was to inhibit adipogenic differentiation by transfecting two growth factors, platelet-derived growth factor (PDGF-BB) and bone morphogenic protein 2 (BMP-2), into modified rat bone marrow mesenchymal stem cells (rBMSCs) and then compounded with platelet-rich plasma (PRP). To achiev...
